Literature DB >> 18295603

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

R Costa1, A Gonçalves, M J Saraiva, I Cardoso.   

Abstract

It has been suggested that transthyretin (TTR) is involved in preventing A-Beta fibrillization in Alzheimer's disease (AD). Here, we characterized the TTR/A-Beta interaction by competition binding assays. TTR binds to different A-Beta peptide species: soluble (Kd, 28 nM), oligomers and fibrils; diverse TTR variants bind differentially to A-Beta. Transmission electron microscopy (TEM) analysis demonstrated that TTR is capable of interfering with A-Beta fibrillization by both inhibiting and disrupting fibril formation. Co-incubation of the two molecules resulted in the abolishment of A-Beta toxicity. Our results confirmed TTR as an A-Beta ligand and indicated the inhibition/disruption of A-Beta fibrils as a possible mechanism underlying the protective role of TTR in AD.

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Year:  2008        PMID： 18295603     DOI： 10.1016/j.febslet.2008.02.034

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  54 in total

1.  Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor.

Authors:  Telma Quintela; Isabel Gonçalves; Ana Martinho; Celso Henrique Alves; Maria João Saraiva; Pedro Rocha; Cecília Reis Alves Santos
Journal:  J Mol Neurosci       Date:  2010-06-10       Impact factor: 3.444

2.  Transthyretin-derived peptides as β-amyloid inhibitors.

Authors:  Patricia Y Cho; Gururaj Joshi; Jeffrey A Johnson; Regina M Murphy
Journal:  ACS Chem Neurosci       Date:  2014-04-09       Impact factor: 4.418

3.  Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?

Authors:  Xinyi Li; Eliezer Masliah; Natàlia Reixach; Joel N Buxbaum
Journal:  J Neurosci       Date:  2011-08-31       Impact factor: 6.167

4.  The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.

Authors:  Xin Wang; Francesca Cattaneo; Lisa Ryno; John Hulleman; Natàlia Reixach; Joel N Buxbaum
Journal:  J Neurosci       Date:  2014-05-21       Impact factor: 6.167

Review 5.  Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.

Authors:  Jinghui Luo; Sebastian K T S Wärmländer; Astrid Gräslund; Jan Pieter Abrahams
Journal:  J Biol Chem       Date:  2016-06-20       Impact factor: 5.157

6.  Transthyretin Mimetics as Anti-β-Amyloid Agents: A Comparison of Peptide and Protein Approaches.

Authors:  Kayla M Pate; Brandon J Kim; Eric V Shusta; Regina M Murphy
Journal:  ChemMedChem       Date:  2018-04-16       Impact factor: 3.466

7.  Mechanisms of transthyretin inhibition of β-amyloid aggregation in vitro.

Authors:  Xinyi Li; Xin Zhang; Ali Reza A Ladiwala; Deguo Du; Jay K Yadav; Peter M Tessier; Peter E Wright; Jeffery W Kelly; Joel N Buxbaum
Journal:  J Neurosci       Date:  2013-12-11       Impact factor: 6.167

Review 8.  The role of transthyretin in cell biology: impact on human pathophysiology.

Authors:  Joana Magalhães; Márcia Almeida Liz; Jessica Eira
Journal:  Cell Mol Life Sci       Date:  2021-07-23       Impact factor: 9.261

9.  Rare Genetic Variants of the Transthyretin Gene Are Associated with Alzheimer's Disease in Han Chinese.

Authors:  Qun Xiang; Rui Bi; Min Xu; Deng-Feng Zhang; Liwen Tan; Chen Zhang; Yiru Fang; Yong-Gang Yao
Journal:  Mol Neurobiol       Date:  2016-08-25       Impact factor: 5.590

10.  Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice.

Authors:  Richard Killick; Georgie Scales; Karelle Leroy; Mirsada Causevic; Claudie Hooper; Elaine E Irvine; Agharul I Choudhury; Laura Drinkwater; Fiona Kerr; Hind Al-Qassab; John Stephenson; Zehra Yilmaz; K Peter Giese; Jean-Pierre Brion; Dominic J Withers; Simon Lovestone
Journal:  Biochem Biophys Res Commun       Date:  2009-06-10       Impact factor: 3.575
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