Literature DB >> 18295493

Ester derivatives of gallic acid with potential toxicity toward L1210 leukemia cells.

Claudriana Locatelli1, Rober Rosso, Maria C Santos-Silva, Camila A de Souza, Marley A Licínio, Paulo Leal, Maria L Bazzo, Rosendo A Yunes, Tânia B Creczynski-Pasa.   

Abstract

Gallic acid and gallates with the same number of hydroxyl groups and varying the length of the side carbon chain, with respective lipophilicity being defined through the ClogP values, were examined for their ability to induce apoptosis (through the DNA ladder fragmentation pattern), mitochondrial and cytoplasmic GSH depletion and NF-kappaB activation in murine lymphoblastic L1210 leukemia cells. A relationship between cytotoxic effect and a limited degree of lipophilicity was observed.

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Year:  2008        PMID： 18295493     DOI： 10.1016/j.bmc.2008.01.049

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  13 in total

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