| Literature DB >> 18295490 |
Yumi Um1, Sungsik Cho, Ho Bum Woo, Yong Kee Kim, Hanna Kim, Jungyeob Ham, Su-Nam Kim, Chan Mug Ahn, Seokjoon Lee.
Abstract
In order to discover novel multidrug resistance (MDR) reversal agents for efficient cancer chemotherapy, the unsymmetrical curcumin mimics with various amide moieties (6-19) were synthesized and evaluated their MDR reversal activities in MDR cell line KBV20C. Among the tested compounds, 13, 16, and 17 showed potent MDR reversal activities by inhibiting drug efflux function of P-glycoprotein in KB20C cells, and almost recovered the cytotoxicity of vincristine and paclitaxel against KBV20C cell to the degree of potency against drug sensitive KB cells.Entities:
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Year: 2008 PMID： 18295490 DOI： 10.1016/j.bmc.2008.02.012
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641