Literature DB >> 1829527

Interaction of hsp70 with unfolded proteins: effects of temperature and nucleotides on the kinetics of binding.

D R Palleros1, W J Welch, A L Fink.   

Abstract

Circular dichroism and HPLC gel filtration were used to show that cytosolic hsp70 is thermally stable but undergoes a conformational transition (midpoint, 43 degrees C; 57 degrees C in the presence of ATP or ADP) leading to oligomerization. hsp70 binds to unfolded, but not to folded, proteins in a temperature-dependent manner; complex formation is significant only at physiologically relevant temperatures. hsp70 binds ADP more tightly than ATP to form a binary complex, which binds to the unfolded protein more rapidly than free hsp70. ADP also inhibits the ATP-induced dissociation of the hsp70-protein complex. A regulatory role for the hsp70-nucleotide binary complexes is proposed.

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Year:  1991        PMID： 1829527      PMCID： PMC51949          DOI： 10.1073/pnas.88.13.5719

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  19 in total

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Journal:  Annu Rev Biochem       Date:  1986       Impact factor: 23.643

Review 2.  Polypeptide chain binding proteins: catalysts of protein folding and related processes in cells.

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Journal:  Cell       Date:  1989-11-17       Impact factor: 41.582

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Journal:  Nature       Date:  1989-05-04       Impact factor: 49.962

5.  Speculations on the functions of the major heat shock and glucose-regulated proteins.

Authors:  H R Pelham
Journal:  Cell       Date:  1986-09-26       Impact factor: 41.582

6.  Homologous plant and bacterial proteins chaperone oligomeric protein assembly.

Authors:  S M Hemmingsen; C Woolford; S M van der Vies; K Tilly; D T Dennis; C P Georgopoulos; R W Hendrix; R J Ellis
Journal:  Nature       Date:  1988-05-26       Impact factor: 49.962

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Authors:  S L Schmid; W A Braell; J E Rothman
Journal:  J Biol Chem       Date:  1985-08-25       Impact factor: 5.157

8.  Heavy-chain binding protein recognizes aberrant polypeptides translocated in vitro.

Authors:  C K Kassenbrock; P D Garcia; P Walter; R B Kelly
Journal:  Nature       Date:  1988-05-05       Impact factor: 49.962

9.  The two mammalian mitochondrial stress proteins, grp 75 and hsp 58, transiently interact with newly synthesized mitochondrial proteins.

Authors:  L A Mizzen; A N Kabiling; W J Welch
Journal:  Cell Regul       Date:  1991-02

10.  The occurrence of polyunsaturated aldehydes in choline-containing phosphoglycerides of a human brain meningioma.

Authors:  O E Bell; C E Cain; L L Sulya; H B White
Journal:  Biochim Biophys Acta       Date:  1967-10-02
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  75 in total

1.  Identification of a Hsp70 recognition domain within the rubisco small subunit transit peptide.

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Journal:  Plant Physiol       Date:  2000-04       Impact factor: 8.340

2.  Quantitative assessment of complex formation of nuclear-receptor accessory proteins.

Authors:  K Graumann; A Jungbauer
Journal:  Biochem J       Date:  2000-02-01       Impact factor: 3.857

3.  A small heat shock protein cooperates with heat shock protein 70 systems to reactivate a heat-denatured protein.

Authors:  G J Lee; E Vierling
Journal:  Plant Physiol       Date:  2000-01       Impact factor: 8.340

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Authors:  S Yalovsky; H Paulsen; D Michaeli; P R Chitnis; R Nechushtai
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-15       Impact factor: 11.205

5.  Spectroscopic and thermodynamic properties of recombinant heat shock protein A6 from Camelus dromedarius.

Authors:  Ajamaluddin Malik; Abuzar Haroon; Haseeb Jagirdar; Abdulrahman M Alsenaidy; Mohamed Elrobh; Wajahatullah Khan; Mohammed S Alanazi; Mohammad D Bazzi
Journal:  Eur Biophys J       Date:  2014-11-14       Impact factor: 1.733

6.  GrpE-like regulation of the hsc70 chaperone by the anti-apoptotic protein BAG-1.

Authors:  J Höhfeld; S Jentsch
Journal:  EMBO J       Date:  1997-10-15       Impact factor: 11.598

7.  Temperature differentially affects adenosine triphosphatase activity in Hsc70 orthologs from Antarctic and New Zealand notothenioid fishes.

Authors:  Sean P Place; Gretchen E Hofmann
Journal:  Cell Stress Chaperones       Date:  2005       Impact factor: 3.667

8.  Interaction of asymmetric ABCC9-encoded nucleotide binding domains determines KATP channel SUR2A catalytic activity.

Authors:  Sungjo Park; Bernard B C Lim; Carmen Perez-Terzic; Georges Mer; Andre Terzic
Journal:  J Proteome Res       Date:  2008-03-01       Impact factor: 4.466

9.  Spinach leaf 70-kilodalton heat-shock cognate stabilizes bovine adrenal glucose-6-phosphate dehydrogenase in vitro without apparent stable binding.

Authors:  J V Anderson; C L Guy
Journal:  Planta       Date:  1995       Impact factor: 4.116

10.  Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis.

Authors:  Ari M Chow; Rohan Steel; Robin L Anderson
Journal:  Cell Stress Chaperones       Date:  2008-09-26       Impact factor: 3.667
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