| Literature DB >> 18294741 |
Filippo Ansaldi1, Sabrina Bacilieri, Paolo Durando, Laura Sticchi, Laura Valle, Emanuele Montomoli, Giancarlo Icardi, Roberto Gasparini, Pietro Crovari.
Abstract
Adjuvants enhance antibody response against vaccination. We compared the ability of MF59-adjuvanted and non-adjuvanted subunit influenza vaccines, containing A/Wyoming/3/03(H3N2), to confer cross-protection against four consecutive drifted strains in the elderly. Neutralizing and haemagglutination-inhibiting antibody were measured. MF59-adjuvanted vaccine induced a stronger booster response against A/Panama/2007/99(H3N2) than non-adjuvanted vaccine. A/Panama/2007/99(H3N2) circulated widely during the previous 5 years and was included in vaccines over four consecutive seasons. Broader serological protection against drifted strains that circulated 1 and 2 years after vaccination with A/Wyoming/3/03(H3N2) was observed with MF59-adjuvanted vaccine. Thus, MF59-adjuvanted vaccine confers greater immunogenicity than non-adjuvanted vaccines in vulnerable populations.Entities:
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Year: 2008 PMID： 18294741 DOI： 10.1016/j.vaccine.2008.01.019
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641