Froilan Granero-Molto1, Jared A Weis, Lara Longobardi, Anna Spagnoli. 1. University of North Carolina at Chapel Hill, Division of Endocrinology, Department of Pediatrics, 3341 Medical Biomolecular Research Building, 103 Mason Farm Road Campus Box: 7039, Chapel Hill North Carolina 27599-7239, USA.
Abstract
BACKGROUND: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. OBJECTIVE: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their regenerative properties and potential applications for cell-based therapies to treat bone and cartilage disorders. METHODS: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. CONCLUSION: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in regenerative medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture healing failure, where treatments are partially effective or palliative.
BACKGROUND: Mesenchymal stem cells (MSC) are multipotent cells with the ability to differentiate into mesenchyme-derived cells including osteoblasts and chondrocytes. OBJECTIVE: To provide an overview and expert opinion on the in vivo ability of MSC to home into tissues, their regenerative properties and potential applications for cell-based therapies to treat bone and cartilage disorders. METHODS: Data sources including the PubMed database, abstract booklets and conference proceedings were searched for publications pertinent to MSC and their properties with emphasis on the in vivo studies and clinical use in cartilage and bone regeneration and repair. The search included the most current information possible. CONCLUSION: MSC can migrate to injured tissues and some of their reparative properties are mediated by paracrine mechanisms including their immunomodulatory actions. MSC possess a critical potential in regenerative medicine for the treatment of skeletal diseases, such as osteoarthritis or fracture healing failure, where treatments are partially effective or palliative.
Authors: Najib El Haddad; Dean Heathcote; Robert Moore; Sunmi Yang; Jamil Azzi; Bechara Mfarrej; Mark Atkinson; Mohamed H Sayegh; Jeng-Shin Lee; Philip G Ashton-Rickardt; Reza Abdi Journal: Blood Date: 2010-11-12 Impact factor: 22.113
Authors: Ganna Bilousova; Du Hyun Jun; Karen B King; Stijn De Langhe; Wallace S Chick; Enrique C Torchia; Kelsey S Chow; Dwight J Klemm; Dennis R Roop; Susan M Majka Journal: Stem Cells Date: 2011-02 Impact factor: 6.277
Authors: Shawn P Grogan; Shigeru Miyaki; Hiroshi Asahara; Darryl D D'Lima; Martin K Lotz Journal: Arthritis Res Ther Date: 2009-06-05 Impact factor: 5.156