OBJECTIVE: The purpose of this study was to investigate whether thoracic ascending aortic aneurysm (TAAA) induces platelet activation as mural thrombus participates in aortic dilatation in abdominal aortic aneurysm and TAAA are associated with rheological factors favoring coagulation activation. METHODS AND RESULTS: We studied the relation between coagulation activation and aortic diameter in Marfan patients (MFS) with various aortic diameters (n=52). We then studied patients presenting large aneurysms associated with bicuspid aortic valve (BAV) and degenerative form. Lastly, we used immunochemistry and biochemistry to investigate prothrombin/thrombin retention within the aortic wall. Microparticles, sGPV, tissue factor, and TAT complexes were increased in plasma from MFS with large aneurysms (>or=45 mm) compared to MFS with limited aortic dilatation (<45 mm). Similar elevations were observed in all patients with large aortic aneurysms, regardless of the etiology, the site of maximal aortic dilation, associated valvulopathy, risk factors, or treatments. P-selectin and platelet-bound fibrinogen were also increased, demonstrating platelet activation in large aneurysms. Significant increase in sCD146 plasma concentration suggested alteration of endothelium. CONCLUSIONS: Platelet activation occurs in patients with large aneurysms of the ascending aorta, is dependent on aortic dilation, and is associated with thrombin generation, part of which appears to be retained in mucoid degeneration areas.
OBJECTIVE: The purpose of this study was to investigate whether thoracic ascending aortic aneurysm (TAAA) induces platelet activation as mural thrombus participates in aortic dilatation in abdominal aortic aneurysm and TAAA are associated with rheological factors favoring coagulation activation. METHODS AND RESULTS: We studied the relation between coagulation activation and aortic diameter in Marfan patients (MFS) with various aortic diameters (n=52). We then studied patients presenting large aneurysms associated with bicuspid aortic valve (BAV) and degenerative form. Lastly, we used immunochemistry and biochemistry to investigate prothrombin/thrombin retention within the aortic wall. Microparticles, sGPV, tissue factor, and TAT complexes were increased in plasma from MFS with large aneurysms (>or=45 mm) compared to MFS with limited aortic dilatation (<45 mm). Similar elevations were observed in all patients with large aortic aneurysms, regardless of the etiology, the site of maximal aortic dilation, associated valvulopathy, risk factors, or treatments. P-selectin and platelet-bound fibrinogen were also increased, demonstrating platelet activation in large aneurysms. Significant increase in sCD146 plasma concentration suggested alteration of endothelium. CONCLUSIONS: Platelet activation occurs in patients with large aneurysms of the ascending aorta, is dependent on aortic dilation, and is associated with thrombin generation, part of which appears to be retained in mucoid degeneration areas.
Authors: Amala P Chirumamilla; Akiko Maehara; Gary S Mintz; Roxana Mehran; Sunil Kanwal; Giora Weisz; Ahmed Hassanin; Diaa Hakim; Ning Guo; Usman Baber; Robert Pyo; Jeffrey W Moses; Martin Fahy; Jason C Kovacic; George D Dangas Journal: JACC Cardiovasc Imaging Date: 2012-05
Authors: A Phillip Owens; Todd L Edwards; Silvio Antoniak; Julia E Geddings; Eiman Jahangir; Wei-Qi Wei; Joshua C Denny; Yacine Boulaftali; Wolfgang Bergmeier; Alan Daugherty; Uchechukwu K A Sampson; Nigel Mackman Journal: Arterioscler Thromb Vasc Biol Date: 2015-07-02 Impact factor: 8.311
Authors: Katharina T I Kornhuber; Heide Seidel; Claudia Pujol; Christian Meierhofer; Franz Röschenthaler; Axel Pressler; Alexander Stöckl; Nicole Nagdyman; Rhoia C Neidenbach; Philipp von Hundelshausen; Martin Halle; Stefan Holdenrieder; Peter Ewert; Harald Kaemmerer; Michael Hauser Journal: Cardiovasc Diagn Ther Date: 2019-10