Literature DB >> 18291691

Narcolepsy: immunological aspects.

Sebastiaan Overeem1, John Logan Black, Gert Jan Lammers.   

Abstract

Narcolepsy with cataplexy is a debilitating sleep disorder with an estimated prevalence of about 0.05%. Narcolepsy is caused by a selective loss of hypocretin (orexin) producing neurons in the perifornical hypothalamus. Based on the very strong association with the HLA subtype DQB1*0602, it is currently hypothesized narcolepsy is caused by an autoimmune-mediated process directed at the hypocretin neurons. So far however, studies focusing on general markers of (auto)immune activation, as well as humoral immunity against the hypocretin system have not yielded consistent results supporting this hypothesis.

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Year:  2008        PMID： 18291691      PMCID： PMC2366136          DOI： 10.1016/j.smrv.2007.07.010

Source DB:  PubMed          Journal:  Sleep Med Rev        ISSN： 1087-0792            Impact factor:   11.609


  98 in total

1.  The frustrating and mostly fruitless search for an autoimmune cause of narcolepsy.

Authors:  Thomas E Scammell
Journal:  Sleep       Date:  2006-05       Impact factor: 5.849

2.  Hypersomnia due to acute disseminated encephalomyelitis in a 5-year-old girl.

Authors:  T Kanbayashi; A Goto; Y Hishikawa; Y Takahashi; Y Saito; Y Ogawa; J Sugawara; G Takada; T Shimizu
Journal:  Sleep Med       Date:  2001-07       Impact factor: 3.492

3.  Reduction of REM sleep latency associated with HLA-DQB1*0602 in normal adults.

Authors:  E Mignot; T Young; L Lin; L Finn; M Palta
Journal:  Lancet       Date:  1998-03-07       Impact factor: 79.321

4.  Search for neuron-specific and nonneuron-specific antibodies in narcoleptic patients with and without HLA DQB1*0602.

Authors:  John Logan Black; Lois E Krahn; V Shane Pankratz; Michael Silber
Journal:  Sleep       Date:  2002-11-01       Impact factor: 5.849

Review 5.  The psychosocial aspects of narcolepsy.

Authors:  N J Douglas
Journal:  Neurology       Date:  1998-02       Impact factor: 9.910

6.  Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.

Authors:  J Hara; C T Beuckmann; T Nambu; J T Willie; R M Chemelli; C M Sinton; F Sugiyama; K Yagami; K Goto; M Yanagisawa; T Sakurai
Journal:  Neuron       Date:  2001-05       Impact factor: 17.173

Review 7.  The epidemiology of narcolepsy.

Authors:  W T Longstreth; Thomas D Koepsell; Thanh G Ton; Audrey F Hendrickson; Gerald van Belle
Journal:  Sleep       Date:  2007-01       Impact factor: 5.849

8.  [Comorbidity in narcoleptic patients].

Authors:  G Mayer; K Kesper; H Peter; T Ploch; T Leinweber; J H Peter
Journal:  Dtsch Med Wochenschr       Date:  2002-09-20       Impact factor: 0.628

9.  Decreased cerebrospinal fluid hypocretin-1 levels near the onset of narcolepsy in 2 prepubertal children.

Authors:  Hiroaki Kubota; Takashi Kanbayashi; Yuzo Tanabe; Masahiro Ito; Jun-ichi Takanashi; Yoichi Kohno; Tetsuo Shimizu
Journal:  Sleep       Date:  2003-08-01       Impact factor: 5.849

10.  Multiple sclerosis and narcolepsy/cataplexy in a monozygotic twin.

Authors:  H Schrader; O B Gotlibsen; G N Skomedal
Journal:  Neurology       Date:  1980-01       Impact factor: 9.910
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  17 in total

1.  Furthering the understanding of the pathophysiology of narcolepsy.

Authors:  Michael J Thorpy
Journal:  Curr Neurol Neurosci Rep       Date:  2011-04       Impact factor: 5.081

2.  Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination.

Authors:  Shuqin Zhan; Guo-Qiang Cai; Anni Zheng; Yuping Wang; Jianping Jia; Haotian Fang; Youfeng Yang; Meng Hu; Qiang Ding
Journal:  Biochim Biophys Acta       Date:  2010-11-18

3.  Anti-Tribbles homolog 2 (TRIB2) autoantibodies in narcolepsy are associated with recent onset of cataplexy.

Authors:  Minae Kawashima; Ling Lin; Susumu Tanaka; Poul Jennum; Stine Knudsen; Sona Nevsimalova; Giuseppe Plazzi; Emmanuel Mignot
Journal:  Sleep       Date:  2010-07       Impact factor: 5.849

Review 4.  The complementary roles of Phase 3 trials and post-licensure surveillance in the evaluation of new vaccines.

Authors:  Pier Luigi Lopalco; Frank DeStefano
Journal:  Vaccine       Date:  2014-11-04       Impact factor: 3.641

Review 5.  Genetics of sleep and sleep disorders.

Authors:  Amita Sehgal; Emmanuel Mignot
Journal:  Cell       Date:  2011-07-22       Impact factor: 41.582

6.  The economic consequences of narcolepsy.

Authors:  Poul Jennum; Stine Knudsen; Jakob Kjellberg
Journal:  J Clin Sleep Med       Date:  2009-06-15       Impact factor: 4.062

7.  Increased immune complexes of hypocretin autoantibodies in narcolepsy.

Authors:  Aude Deloumeau; Sophie Bayard; Quentin Coquerel; Pierre Déchelotte; Christine Bole-Feysot; Bertrand Carlander; Valérie Cochen De Cock; Sergueï O Fetissov; Yves Dauvilliers
Journal:  PLoS One       Date:  2010-10-13       Impact factor: 3.240

8.  Animal models of narcolepsy.

Authors:  Lichao Chen; Ritchie E Brown; James T McKenna; Robert W McCarley
Journal:  CNS Neurol Disord Drug Targets       Date:  2009-08       Impact factor: 4.388

Review 9.  A practical approach to the diagnosis and management of sleep disorders in patients with multiple sclerosis.

Authors:  Tiffany J Braley; Ronald D Chervin
Journal:  Ther Adv Neurol Disord       Date:  2015-11       Impact factor: 6.570

Review 10.  The autoimmune basis of narcolepsy.

Authors:  Josh Mahlios; Alberto K De la Herrán-Arita; Emmanuel Mignot
Journal:  Curr Opin Neurobiol       Date:  2013-05-29       Impact factor: 6.627
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