OBJECTIVE: To examine the relationship of male obesity and reproductive function. DESIGN: Observational study. SETTING: Academic medical center. PATIENT(S): Eighty-seven adult men, body mass index (BMI) range from 16.1 to 47.0 kg/m(2) (mean = 29.3 kg/m(2); SD = 6.5 kg/m(2)). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Reproductive history, physical examination, inhibin B, FSH, LH, T, and unbound T levels, and semen analysis. RESULT(S): Body mass index was negatively correlated with testosterone (r = -0.38), FSH (r = -0.22), and inhibin B levels (r = -0.21) and was positively correlated with E(2) levels (r = 0.34). Testosterone also negatively correlated with skinfold thickness (r = -0.30). There was no correlation of BMI or skinfold thickness with semen analysis parameters (sperm density, volume, motility, or morphology). Inhibin B level correlated significantly with sperm motility (r = 0.23). Men with paternity had lower BMIs (28.0 kg/m(2) vs. 31.6 kg/m(2)) and lower skinfold thickness (24.7 mm vs. 34.1 mm) than men without. CONCLUSION(S): Obesity is an infertility factor in otherwise normal men. Obese men demonstrate a relative hypogonadotropic hypogonadism. Reduced inhibin B levels and diminished paternity suggest compromised reproductive capacity in this population.
OBJECTIVE: To examine the relationship of male obesity and reproductive function. DESIGN: Observational study. SETTING: Academic medical center. PATIENT(S): Eighty-seven adult men, body mass index (BMI) range from 16.1 to 47.0 kg/m(2) (mean = 29.3 kg/m(2); SD = 6.5 kg/m(2)). INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Reproductive history, physical examination, inhibin B, FSH, LH, T, and unbound T levels, and semen analysis. RESULT(S): Body mass index was negatively correlated with testosterone (r = -0.38), FSH (r = -0.22), and inhibin B levels (r = -0.21) and was positively correlated with E(2) levels (r = 0.34). Testosterone also negatively correlated with skinfold thickness (r = -0.30). There was no correlation of BMI or skinfold thickness with semen analysis parameters (sperm density, volume, motility, or morphology). Inhibin B level correlated significantly with sperm motility (r = 0.23). Men with paternity had lower BMIs (28.0 kg/m(2) vs. 31.6 kg/m(2)) and lower skinfold thickness (24.7 mm vs. 34.1 mm) than men without. CONCLUSION(S): Obesity is an infertility factor in otherwise normal men. Obese men demonstrate a relative hypogonadotropic hypogonadism. Reduced inhibin B levels and diminished paternity suggest compromised reproductive capacity in this population.
Authors: Katherine Esposito; Francesco Giugliano; Carmen Di Palo; Giovanni Giugliano; Raffaele Marfella; Francesco D'Andrea; Massimo D'Armiento; Dario Giugliano Journal: JAMA Date: 2004-06-23 Impact factor: 56.272
Authors: C A de Gouveia Brazao; F H Pierik; Y Erenpreiss; F H de Jong; G R Dohle; R F A Weber Journal: Clin Endocrinol (Oxf) Date: 2003-07 Impact factor: 3.478
Authors: Alex J Polotsky; Amanda A Allshouse; Peter R Casson; Christos Coutifaris; Michael P Diamond; Gregory M Christman; William D Schlaff; Ruben Alvero; J C Trussell; Stephen A Krawetz; Nanette Santoro; Esther Eisenberg; Heping Zhang; Richard S Legro Journal: J Clin Endocrinol Metab Date: 2015-04-09 Impact factor: 5.958
Authors: Stefan S Du Plessis; Stephanie Cabler; Debra A McAlister; Edmund Sabanegh; Ashok Agarwal Journal: Nat Rev Urol Date: 2010-02-16 Impact factor: 14.432
Authors: Richard S Legro; Allen R Kunselman; Juliana W Meadows; James S Kesner; Edward F Krieg; Ann M Rogers; Robert N Cooney Journal: Reprod Biomed Online Date: 2014-11-05 Impact factor: 3.828
Authors: N Sermondade; C Faure; L Fezeu; A G Shayeb; J P Bonde; T K Jensen; M Van Wely; J Cao; A C Martini; M Eskandar; J E Chavarro; S Koloszar; J M Twigt; C H Ramlau-Hansen; E Borges; F Lotti; R P M Steegers-Theunissen; B Zorn; A J Polotsky; S La Vignera; B Eskenazi; K Tremellen; E V Magnusdottir; I Fejes; S Hercberg; R Lévy; S Czernichow Journal: Hum Reprod Update Date: 2012-12-12 Impact factor: 15.610