| Literature DB >> 18289862 |
Kumiko Sako1, Hiroshi Aoyama, Shinichi Sato, Yuichi Hashimoto, Masanori Baba.
Abstract
Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.Entities:
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Year: 2008 PMID： 18289862 DOI： 10.1016/j.bmc.2008.01.052
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641