Literature DB >> 18289857

Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template.

John Spencer1, John Gaffen, Eric Griffin, Elaine A Harper, Ian D Linney, Iain M McDonald, Sonia P Roberts, Mark E Shaxted, Trushar Adatia, Alan Bashall.   

Abstract

Novel, achiral 1H-1,3,5-benzotriazepine-2,4(3H,5H)-diones have been prepared and structurally characterized. These compounds are potent CCK(2) receptor antagonists that display a high degree of selectivity over CCK(1) receptors.

Entities:  

Mesh:

Substances:

Year:  2007        PMID: 18289857     DOI: 10.1016/j.bmc.2007.12.047

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN: 0968-0896            Impact factor:   3.641


  1 in total

1.  2-Amino-N'-phenyl-benzohydrazide.

Authors:  Víctor Kesternich; Paulo Gahona; Marcia Pérez-Fehrmann; Iván Brito; Matías López-Rodríguez
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-23
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.