| Literature DB >> 18289852 |
Stephen Hanessian1, Daniel Simard, Malken Bayrakdarian, Eric Therrien, Ingemar Nilsson, Ola Fjellström.
Abstract
Guided by available X-ray crystal structure data on the serine protease thrombin, a series of pyridin-2-one derivatives were designed and synthesized having diverse functionality at the P(1) and P(3) sites. Potent in vitro activity against thrombin, with excellent selectivity over trypsin was found for selected analogues.Entities:
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Year: 2008 PMID： 18289852 DOI： 10.1016/j.bmcl.2008.01.122
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823