Literature DB >> 1828948

T-cell receptor isoforms and signal transduction.

S Koyasu1, L D'Adamio, L K Clayton, E L Reinherz.   

Abstract

Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.

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Year:  1991        PMID： 1828948     DOI： 10.1016/0952-7915(91)90073-a

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  4 in total

1.  Developmental regulation of TCR-CD3-dependent [Ca2+]i responses of individual normal and pp59fyn-deficient T lymphocytes.

Authors:  K E Hedin; M W Appleby; D E Clapham
Journal:  Immunology       Date:  1995-02       Impact factor: 7.397

2.  Different roles for the Fc epsilon RI gamma chain as a function of the receptor context.

Authors:  R Paolini; V Renard; E Vivier; K Ochiai; M H Jouvin; B Malissen; J P Kinet
Journal:  J Exp Med       Date:  1995-01-01       Impact factor: 14.307

3.  Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

Authors:  H Ohno; T Aoe; S Taki; D Kitamura; Y Ishida; K Rajewsky; T Saito
Journal:  EMBO J       Date:  1993-11       Impact factor: 11.598

4.  T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytes.

Authors:  S Koyasu; L D'Adamio; A R Arulanandam; S Abraham; L K Clayton; E L Reinherz
Journal:  J Exp Med       Date:  1992-01-01       Impact factor: 14.307
  4 in total

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