Literature DB >> 18289072

The role of heme oxygenase-1 in T cell-mediated immunity: the all encompassing enzyme.

Z W Xia1, W W Zhong, J S Meyrowitz, Z L Zhang.   

Abstract

Heme oxygenase-1 (HO-1) is the rate-limiting enzyme of ferroheme metabolic pathway, which has the functions of anti-oxidation, anti-inflammatory, anti-apoptosis and anti-smooth muscle hyperplasia. Furthermore, HO-1 exerts a protective action in the diseases mediated by effector T lymphocytes such as T helper (Th) 1, Th2 and Th17. In addition, regulatory T cells (Treg) control the activity of CD4+CD25- effector cells in a suppressive manner. Numerous studies indicate that the protective action of HO-1 in diseases is through CD4+CD25+ Treg. This paper will review the current research and understanding of HO-1's role in T cells-mediated immunoregulation.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18289072     DOI： 10.2174/138161208783597326

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  12 in total

1.  Cytoprotection behind heme oxygenase-1 in renal diseases.

Authors:  Matheus Correa-Costa; Mariane Tami Amano; Niels Olsen Saraiva Câmara
Journal:  World J Nephrol       Date:  2012-02-06

2.  Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

Authors:  Stefano Di Biase; Changhan Lee; Sebastian Brandhorst; Brianna Manes; Roberta Buono; Chia-Wei Cheng; Mafalda Cacciottolo; Alejandro Martin-Montalvo; Rafael de Cabo; Min Wei; Todd E Morgan; Valter D Longo
Journal:  Cancer Cell       Date:  2016-07-11       Impact factor: 31.743

3.  Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs.

Authors:  Magdalena Kozakowska; Krzysztof Szade; Jozef Dulak; Alicja Jozkowicz
Journal:  Antioxid Redox Signal       Date:  2014-01-30       Impact factor: 8.401

4.  Heme oxygenase-1 ameliorates dextran sulfate sodium-induced acute murine colitis by regulating Th17/Treg cell balance.

Authors:  Liya Zhang; Yanjie Zhang; Wenwei Zhong; Caixia Di; Xiaoliang Lin; Zhenwei Xia
Journal:  J Biol Chem       Date:  2014-08-11       Impact factor: 5.157

5.  Heme oxygenase-1 inhibits basophil maturation and activation but promotes its apoptosis in T helper type 2-mediated allergic airway inflammation.

Authors:  Wenwei Zhong; Caixia Di; Jiajia Lv; Yanjie Zhang; Xiaoliang Lin; Yufan Yuan; Jie Lv; Zhenwei Xia
Journal:  Immunology       Date:  2016-02-08       Impact factor: 7.397

6.  Identification of heme oxygenase-1-specific regulatory CD8+ T cells in cancer patients.

Authors:  Mads Hald Andersen; Rikke Baek Sørensen; Marie K Brimnes; Inge Marie Svane; Jürgen C Becker; Per thor Straten
Journal:  J Clin Invest       Date:  2009-08       Impact factor: 14.808

7.  Candida albicans heme oxygenase and its product CO contribute to pathogenesis of candidemia and alter systemic chemokine and cytokine expression.

Authors:  Dhammika H M L P Navarathna; David D Roberts
Journal:  Free Radic Biol Med       Date:  2010-08-25       Impact factor: 7.376

Review 8.  Therapeutic potential of HO-1 in autoimmune diseases.

Authors:  Bao-Zhu Li; Biao Guo; Hai-Yan Zhang; Juan Liu; Sha-Sha Tao; Hai-Feng Pan; Dong-Qing Ye
Journal:  Inflammation       Date:  2014-10       Impact factor: 4.092

9.  Unveiling the association of STAT3 and HO-1 in prostate cancer: role beyond heme degradation.

Authors:  Belen Elguero; Geraldine Gueron; Jimena Giudice; Martin A Toscani; Paola De Luca; Florencia Zalazar; Federico Coluccio-Leskow; Roberto Meiss; Nora Navone; Adriana De Siervi; Elba Vazquez
Journal:  Neoplasia       Date:  2012-11       Impact factor: 5.715

10.  Heme oxygenase-1 protects regulatory T cells from hypoxia-induced cellular stress in an experimental mouse brain tumor model.

Authors:  Mahua Dey; Alan L Chang; Derek A Wainwright; Atique U Ahmed; Yu Han; Irina V Balyasnikova; Maciej S Lesniak
Journal:  J Neuroimmunol       Date:  2013-11-08       Impact factor: 3.478
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.