Literature DB >> 18289068

Heme oxygenase: a target gene for anti-diabetic and obesity.

N G Abraham1, P L Tsenovoy, J McClung, G S Drummond.   

Abstract

Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.

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Year:  2008        PMID： 18289068     DOI： 10.2174/138161208783597371

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  27 in total

1.  Deletion of soluble epoxide hydrolase gene improves renal endothelial function and reduces renal inflammation and injury in streptozotocin-induced type 1 diabetes.

Authors:  Ahmed A Elmarakby; Jessica Faulkner; Mohammed Al-Shabrawey; Mong-Heng Wang; Krishna Rao Maddipati; John D Imig
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2011-08-10       Impact factor: 3.619

Review 2.  Innate immunity and heat shock response in islet transplantation.

Authors:  Y Lai; C Chen; T Linn
Journal:  Clin Exp Immunol       Date:  2009-02-04       Impact factor: 4.330

Review 3.  HO-1 overexpression and underexpression: Clinical implications.

Authors:  George S Drummond; Jeffrey Baum; Menachem Greenberg; David Lewis; Nader G Abraham
Journal:  Arch Biochem Biophys       Date:  2019-08-16       Impact factor: 4.013

4.  Endothelial progenitor cell function inversely correlates with long-term glucose control in diabetic patients: association with the attenuation of the heme oxygenase-adiponectin axis.

Authors:  Yossi Issan; Edith Hochhauser; Ran Kornowski; Dorit Leshem-Lev; Eli Lev; Ram Sharoni; Luca Vanella; Nitin Puri; Michal Laniado-Schwartzman; Nader G Abraham; Eyal Porat
Journal:  Can J Cardiol       Date:  2012-03-23       Impact factor: 5.223

Review 5.  Heme oxygenase in the regulation of vascular biology: from molecular mechanisms to therapeutic opportunities.

Authors:  Young-Myeong Kim; Hyun-Ock Pae; Jeong Euy Park; Yong Chul Lee; Je Moon Woo; Nam-Ho Kim; Yoon Kyung Choi; Bok-Soo Lee; So Ri Kim; Hun-Taeg Chung
Journal:  Antioxid Redox Signal       Date:  2010-10-26       Impact factor: 8.401

Review 6.  Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.

Authors:  Nader G Abraham; Joshua M Junge; George S Drummond
Journal:  Trends Pharmacol Sci       Date:  2015-10-26       Impact factor: 14.819

Review 7.  Epoxyeicosatrienoic acids and heme oxygenase-1 interaction attenuates diabetes and metabolic syndrome complications.

Authors:  Angela Burgess; Luca Vanella; Lars Bellner; Michal L Schwartzman; Nader G Abraham
Journal:  Prostaglandins Other Lipid Mediat       Date:  2011-11-15       Impact factor: 3.072

8.  Effect of different doses of aerobic exercise training on total bilirubin levels.

Authors:  Damon L Swift; Neil M Johannsen; Conrad P Earnest; Steven N Blair; Timothy S Church
Journal:  Med Sci Sports Exerc       Date:  2012-04       Impact factor: 5.411

9.  L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice.

Authors:  Stephen J Peterson; George Drummond; Dong Hyun Kim; Ming Li; Adam L Kruger; Susumu Ikehara; Nader G Abraham
Journal:  J Lipid Res       Date:  2008-04-19       Impact factor: 5.922

10.  Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin.

Authors:  Gianmario Sambuceti; Silvia Morbelli; Luca Vanella; Claudia Kusmic; Cecilia Marini; Michela Massollo; Carla Augeri; Mirko Corselli; Chiara Ghersi; Barbara Chiavarina; Luigi F Rodella; Antonio L'Abbate; George Drummond; Nader G Abraham; Francesco Frassoni
Journal:  Stem Cells       Date:  2009-02       Impact factor: 6.277
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