Literature DB >> 18289042

RNAi screening for therapeutic targets in human malignancies.

David R Micklem1, James B Lorens.   

Abstract

The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 18289042     DOI： 10.2174/138920107783018426

Source DB:  PubMed          Journal:  Curr Pharm Biotechnol        ISSN： 1389-2010            Impact factor:   2.837


  9 in total

1.  UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents.

Authors:  Yanhui Hu; Charles Roesel; Ian Flockhart; Lizabeth Perkins; Norbert Perrimon; Stephanie E Mohr
Journal:  Genetics       Date:  2013-06-21       Impact factor: 4.562

2.  Lentivirus-mediated TPD52L2 depletion inhibits the proliferation of liver cancer cells in vitro.

Authors:  Ze-Ya Pan; Yun Yang; Hao Pan; Jin Zhang; Hui Liu; Yuan Yang; Gang Huang; Lei Yin; Jian Huang; Wei-Ping Zhou
Journal:  Int J Clin Exp Med       Date:  2015-02-15

3.  Synthetic protection short interfering RNA screen reveals glyburide as a novel radioprotector.

Authors:  Jianfei Jiang; Peter R McDonald; Tracy M Dixon; Darcy Franicola; Xichen Zhang; Suhua Nie; Laura D Epperly; Zhentai Huang; Valerian E Kagan; John S Lazo; Michael W Epperly; Joel S Greenberger
Journal:  Radiat Res       Date:  2009-10       Impact factor: 2.841

4.  Posttranslational protein knockdown coupled to receptor tyrosine kinase activation with phosphoPROTACs.

Authors:  John Hines; Jonathan D Gough; Timothy W Corson; Craig M Crews
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-14       Impact factor: 11.205

Review 5.  MicroRNAs: control and loss of control in human physiology and disease.

Authors:  Min Li; Christian Marin-Muller; Uddalak Bharadwaj; Kwong-Hon Chow; Qizhi Yao; Changyi Chen
Journal:  World J Surg       Date:  2009-04       Impact factor: 3.352

6.  Biological effects of RNAi targeted inhibiting Tiam1 gene expression on cholangiocarcinoma cells.

Authors:  Wei Cheng; Yaling Liu; Zhi Zuo; Xinmin Yin; Bo Jiang; Daojin Chen; Chuang Peng; Jianhui Yang
Journal:  Int J Clin Exp Pathol       Date:  2015-12-01

7.  Identification of glycogen synthase kinase 3α as a therapeutic target in melanoma.

Authors:  SubbaRao V Madhunapantula; Arati Sharma; Raghavendra Gowda; Gavin P Robertson
Journal:  Pigment Cell Melanoma Res       Date:  2013-09-19       Impact factor: 4.693

8.  Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells.

Authors:  Liyong Huang; Ye Xu; Guoxiang Cai; Zuqing Guan; Sanjun Cai
Journal:  Oncol Rep       Date:  2011-12-20       Impact factor: 3.906

9.  Lentivirus-mediated RNA interference of tripartite motif 68 inhibits the proliferation of colorectal cancer cell lines SW1116 and HCT116 in vitro.

Authors:  Zhen Tan; Xiaoshuang Liu; Enda Yu; Hantao Wang; Lijun Tang; Hao Wang; Chuangang Fu
Journal:  Oncol Lett       Date:  2017-02-28       Impact factor: 2.967
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.