Literature DB >> 1828708

The calcium antagonist PN 200-110 inhibits the reinforcing properties of cocaine.

L Pani1, A Kuzmin, M C Martellotta, G L Gessa, W Fratta.   

Abstract

The effect of a dihydropyridine (DHP) calcium antagonist, PN 200-110, on cocaine reinforcing properties was investigated using conditioned place preference paradigm. PN 200-110 in nonsedative doses (0.62-1.25-2.5 mg/kg SC) was able to inhibit cocaine-(10 mg/kg IP) induced place preference with ED50 1.57 (0.88-2.58). The results suggest a possible use of DHPs in the treatment of cocaine-related disorders.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1828708     DOI： 10.1016/0361-9230(91)90022-c

Source DB:  PubMed          Journal:  Brain Res Bull        ISSN： 0361-9230            Impact factor:   4.077


  12 in total

Review 1.  Psychopharmacological properties of calcium channel inhibitors.

Authors:  O Pucilowski
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Repeated cocaine modifies the mechanism by which amphetamine releases dopamine.

Authors:  R C Pierce; P W Kalivas
Journal:  J Neurosci       Date:  1997-05-01       Impact factor: 6.167

Review 3.  From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms.

Authors:  Zeeba D Kabir; Arlene Martínez-Rivera; Anjali M Rajadhyaksha
Journal:  Neurotherapeutics       Date:  2017-07       Impact factor: 7.620

Review 4.  Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction.

Authors:  Heath D Schmidt; R Christopher Pierce
Journal:  Ann N Y Acad Sci       Date:  2010-02       Impact factor: 5.691

5.  Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats.

Authors:  Yao-Ying Ma; Peng Yu; Chang-Yong Guo; Cai-Lian Cui
Journal:  Neurochem Res       Date:  2010-12-09       Impact factor: 3.996

6.  L-type Ca2+ channels mediate adaptation of extracellular signal-regulated kinase 1/2 phosphorylation in the ventral tegmental area after chronic amphetamine treatment.

Authors:  Anjali Rajadhyaksha; Isabelle Husson; Shirish S Satpute; Karsten D Küppenbender; J Q Ren; Rejean M Guerriero; David G Standaert; Barry E Kosofsky
Journal:  J Neurosci       Date:  2004-08-25       Impact factor: 6.167

7.  A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice.

Authors:  C D Bryant; H P Chang; J Zhang; T Wiltshire; L M Tarantino; A A Palmer
Journal:  Genes Brain Behav       Date:  2009-07-21       Impact factor: 3.449

8.  Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats.

Authors:  M T Martin-Iverson; A R Reimer
Journal:  Psychopharmacology (Berl)       Date:  1994-03       Impact factor: 4.530

9.  Augmented behavioral response and enhanced synaptosomal calcium transport induced by repeated cocaine administration are decreased by calcium channel blockers.

Authors:  K Mills; T A Ansah; S F Ali; S Mukherjee; D C Shockley
Journal:  Life Sci       Date:  2007-07-18       Impact factor: 5.037

10.  Nimodipine and haloperidol attenuate behavioural sensitization to cocaine but only nimodipine blocks the establishment of conditioned locomotion induced by cocaine.

Authors:  A R Reimer; M T Martin-Iverson
Journal:  Psychopharmacology (Berl)       Date:  1994-01       Impact factor: 4.530
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.