AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers. METHODS: Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group II with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system. RESULTS: Mitochondria, nuclei, RER and SER injury scores in group II were significantly lower than those in group I (P < 0.001). CONCLUSION: UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.
AIM: To examine the ultrastructural changes after ursodeoxycholic acid (UDCA) treatment in hepatocytes from experimentally induced fibrotic livers. METHODS:Liver fibrosis was induced in male Sprague-Dawley rats with CCl4 for 12 wk, and the rats were divided into two groups. Group I was treated with saline and group II with UDCA (25 mg/kg per day) for 4 wk. All the rats were killed at wk 16. Mitochondria, nuclei, rough endoplasmic reticulum (RER) and smooth endoplasmic reticulum (SER) of hepatocytes were evaluated according to a scoring system. RESULTS: Mitochondria, nuclei, RER and SER injury scores in group II were significantly lower than those in group I (P < 0.001). CONCLUSION:UDCA alleviates hepatocyte organelle injury in CCl4-induced liver fibrosis.
Authors: Yuksel Ates; Mehmet R Mas; Nuket Mas; Ilker Tasci; Bilgin Comert; Ahmet T Isik; Nuran Yener Journal: Saudi Med J Date: 2006-04 Impact factor: 1.484
Authors: R Hernández-Muñoz; M Díaz-Muñoz; V López; F López-Barrera; L Yáñez; S Vidrio; A Aranda-Fraustro; V Chagoya de Sánchez Journal: Hepatology Date: 1997-11 Impact factor: 17.425
Authors: Vyacheslav U Buko; Oxana Y Lukivskaya; Elena E Naruta; Elena B Belonovskaya; Horst-Dietmar Tauschel Journal: J Clin Exp Hepatol Date: 2014-02-21