BACKGROUND: A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation. METHODS: Ten MZ twin pairs requested ovarian transplantation and eight have undergone transplantation with cryopreservation of spare tissue. Seven had a fresh cortical tissue transplant, one of whom received a second frozen-thawed transplant after the first ceased functioning at three years. One had a fresh microvascular transplant. RESULTS: All recipients reinitiated ovulatory menstrual cycles and normal Day 3 serum FSH levels by 77-142 days. Six have already conceived naturally (one twice). Currently, two healthy babies have been delivered, and another three pregnancies are ongoing. The oldest transplant functioned for 36 months, resulting in one child and one miscarriage. She conceived again after a frozen-thawed secondary transplant. There was no apparent difference in return of ovarian function between the eight fresh ovarian grafts and the one frozen graft. CONCLUSIONS: Ovarian transplantation appears to restore ovulatory function robustly. Successful pregnancies, including one after cryopreservation, bode well for application to fertility preservation.
BACKGROUND: A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation. METHODS: Ten MZ twin pairs requested ovarian transplantation and eight have undergone transplantation with cryopreservation of spare tissue. Seven had a fresh cortical tissue transplant, one of whom received a second frozen-thawed transplant after the first ceased functioning at three years. One had a fresh microvascular transplant. RESULTS: All recipients reinitiated ovulatory menstrual cycles and normal Day 3 serum FSH levels by 77-142 days. Six have already conceived naturally (one twice). Currently, two healthy babies have been delivered, and another three pregnancies are ongoing. The oldest transplant functioned for 36 months, resulting in one child and one miscarriage. She conceived again after a frozen-thawed secondary transplant. There was no apparent difference in return of ovarian function between the eight fresh ovarian grafts and the one frozen graft. CONCLUSIONS: Ovarian transplantation appears to restore ovulatory function robustly. Successful pregnancies, including one after cryopreservation, bode well for application to fertility preservation.
Authors: Andreas Müller; Katja Keller; Jennifer Wacker; Ralf Dittrich; Gudrun Keck; Markus Montag; Hans Van der Ven; David Wachter; Matthias W Beckmann; Wolfgang Distler Journal: Dtsch Arztebl Int Date: 2012-01-09 Impact factor: 5.594
Authors: Mary Ellen Pavone; Jennifer Hirshfeld-Cytron; Candace Tingen; Cristina Thomas; Jessina Thomas; M Patrick Lowe; Julian C Schink; Teresa K Woodruff Journal: Reprod Sci Date: 2013-10-04 Impact factor: 3.060
Authors: Jing Xu; Min Xu; Marcelo P Bernuci; Thomas E Fisher; Lonnie D Shea; Teresa K Woodruff; Mary B Zelinski; Richard L Stouffer Journal: Adv Exp Med Biol Date: 2013 Impact factor: 2.622
Authors: Rachel M Smith; Ariella Shikanov; Ekaterina Kniazeva; Deepa Ramadurai; Teresa K Woodruff; Lonnie D Shea Journal: Tissue Eng Part A Date: 2014-06-12 Impact factor: 3.845