BACKGROUND: Lack of circumcision has been identified as a risk factor for male genital human papillomavirus (HPV) infection, although this association has not been consistently supported. METHODS: Specimens for HPV testing were collected from a cohort of 379 (primarily heterosexual) adult males. HPV prevalence in the glans penis and coronal sulcus, penile shaft, scrotum, semen, and urine was compared by circumcision status. RESULTS: Overall, HPV DNA prevalence ranged from 6% in semen to 52% in the penile shaft. The prevalence of any HPV infection in the glans/corona was significantly higher in uncircumcised men (46%) than in circumcised men (29%) (odds ratio [OR], 1.96 [95% confidence interval (CI), 1.02-3.75], adjusted for demographic characteristics and sexual history). Uncircumcised men also had an increased risk of oncogenic HPV infection (adjusted OR, 2.51 [95% CI, 1.11-5.69]) and infection with multiple HPV types (adjusted OR, 3.56 [95% CI, 1.50-8.50]). Among uncircumcised men, HPV prevalence in the foreskin (44%) was comparable to that in the glans/corona, and type-specific positivity was observed between the 2 sites (kappa=0.52). CONCLUSIONS: Uncircumcised men have an increased risk of HPV infection, including with oncogenic HPV, specifically localized to the glans/corona, possibly because of its proximity to the foreskin, which may be particularly vulnerable to infection.
BACKGROUND: Lack of circumcision has been identified as a risk factor for male genital human papillomavirus (HPV) infection, although this association has not been consistently supported. METHODS: Specimens for HPV testing were collected from a cohort of 379 (primarily heterosexual) adult males. HPV prevalence in the glans penis and coronal sulcus, penile shaft, scrotum, semen, and urine was compared by circumcision status. RESULTS: Overall, HPV DNA prevalence ranged from 6% in semen to 52% in the penile shaft. The prevalence of any HPV infection in the glans/corona was significantly higher in uncircumcised men (46%) than in circumcised men (29%) (odds ratio [OR], 1.96 [95% confidence interval (CI), 1.02-3.75], adjusted for demographic characteristics and sexual history). Uncircumcised men also had an increased risk of oncogenic HPV infection (adjusted OR, 2.51 [95% CI, 1.11-5.69]) and infection with multiple HPV types (adjusted OR, 3.56 [95% CI, 1.50-8.50]). Among uncircumcised men, HPV prevalence in the foreskin (44%) was comparable to that in the glans/corona, and type-specific positivity was observed between the 2 sites (kappa=0.52). CONCLUSIONS: Uncircumcised men have an increased risk of HPV infection, including with oncogenic HPV, specifically localized to the glans/corona, possibly because of its proximity to the foreskin, which may be particularly vulnerable to infection.
Authors: P E Gravitt; C L Peyton; T Q Alessi; C M Wheeler; F Coutlée; A Hildesheim; M H Schiffman; D R Scott; R J Apple Journal: J Clin Microbiol Date: 2000-01 Impact factor: 5.948
Authors: L A Brinton; J Y Li; S D Rong; S Huang; B S Xiao; B G Shi; Z J Zhu; M H Schiffman; S Dawsey Journal: Int J Cancer Date: 1991-02-20 Impact factor: 7.396
Authors: M A Picconi; A M Eiján; A L Distéfano; S Pueyo; L V Alonio; S Gorostidi; A R Teyssié; A Casabé Journal: J Med Virol Date: 2000-05 Impact factor: 2.327
Authors: Janet R Daling; Margaret M Madeleine; Stephen M Schwartz; Katherine A Shera; Joseph J Carter; Barbara McKnight; Peggy L Porter; Denise A Galloway; James K McDougall; Hisham Tamimi Journal: Gynecol Oncol Date: 2002-02 Impact factor: 5.482
Authors: Susie B Baldwin; Danelle R Wallace; Mary R Papenfuss; Martha Abrahamsen; Linda C Vaught; Anna R Giuliano Journal: Sex Transm Dis Date: 2004-10 Impact factor: 2.830
Authors: Brenda Y Hernandez; Yurii B Shvetsov; Marc T Goodman; Lynne R Wilkens; Pamela Thompson; Xuemei Zhu; Lily Ning Journal: J Infect Dis Date: 2010-05-01 Impact factor: 5.226
Authors: Brenda Y Hernandez; Lynne R Wilkens; Pamela J Thompson; Yurii B Shvetsov; Marc T Goodman; Lily Ning; Lana Kaopua Journal: Hum Vaccin Date: 2010-06-01
Authors: Danielle M Backes; Maaike C G Bleeker; Chris J L M Meijer; Michael G Hudgens; Kawango Agot; Robert C Bailey; J O Ndinya-Achola; Juma Hayombe; Cornelis J A Hogewoning; Stephen Moses; Peter J F Snijders; Jennifer S Smith Journal: Int J Cancer Date: 2011-08-02 Impact factor: 7.396
Authors: Brenda Y Hernandez; Jill Barnholtz-Sloan; Robert R German; Anna Giuliano; Marc T Goodman; Jessica B King; Serban Negoita; Jose M Villalon-Gomez Journal: Cancer Date: 2008-11-15 Impact factor: 6.860
Authors: Rachel T Esra; Abraham J Olivier; Jo-Ann S Passmore; Heather B Jaspan; Rushil Harryparsad; Clive M Gray Journal: Front Immunol Date: 2016-06-24 Impact factor: 7.561
Authors: John N Krieger; Supriya D Mehta; Robert C Bailey; Kawango Agot; Jeckoniah O Ndinya-Achola; Corette Parker; Stephen Moses Journal: J Sex Med Date: 2008-08-28 Impact factor: 3.802