Literature DB >> 18282478

Interleukin-1 receptor antagonist (IL-1ra) modulates endothelial cell proliferation.

Rachael M Dewberry1, Andrea R King, David C Crossman, Sheila E Francis.   

Abstract

Endothelial cell (EC) lifespan controlled by the IL-1 family of cytokines is an important determinant of susceptibility to artery wall disease. Here we show that EC lacking intracellular interleukin-1 receptor antagonist (IL-1ra) have a reduced lifespan compared to controls. Over expression of IL-1ra enhanced proliferation via cyclin dependent kinase 2 activity and retinoblastoma protein phosphorylation. This was not seen in EC lacking IL-1 receptor 1 (IL-1 signalling ability), nor apparent using other stimuli e.g. TNF alpha. These data suggest that IL-1ra has a specific and receptor-dependent function to control the growth and lifespan of EC.

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Year:  2008        PMID： 18282478     DOI： 10.1016/j.febslet.2008.02.021

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Mechanical signals activate vascular endothelial growth factor receptor-2 to upregulate endothelial cell proliferation during inflammation.

Authors:  Jie Liu; Sudha Agarwal
Journal:  J Immunol       Date:  2010-06-14       Impact factor: 5.422

2.  Proximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation.

Authors:  Juquan Song; Steven E Wolf; Xiao-Wu Wu; Celeste C Finnerty; David N Herndon; Marc G Jeschke
Journal:  J Surg Res       Date:  2010-04-21       Impact factor: 2.192

3.  A novel bifunctional protein TNFR2-Fc-IL-1ra (TFI): expression, purification and its neutralization activity of inflammatory factors.

Authors:  Bo Xie; Shan Liu; Shuyin Wu; Alan Chang; Weiyuan Jin; Zhixiang Guo; Shuaidong Ye; Mizhou Hui
Journal:  Mol Biotechnol       Date:  2013-06       Impact factor: 2.695

4.  Peripheral Blood Cytokine Levels After Acute Myocardial Infarction: IL-1β- and IL-6-Related Impairment of Bone Marrow Function.

Authors:  Mahan Shahrivari; Elizabeth Wise; Micheline Resende; Jonathan J Shuster; Jingnan Zhang; Roberto Bolli; John P Cooke; Joshua M Hare; Timothy D Henry; Aisha Khan; Doris A Taylor; Jay H Traverse; Phillip C Yang; Carl J Pepine; Christopher R Cogle
Journal:  Circ Res       Date:  2017-05-10       Impact factor: 17.367

5.  Interleukin-1 receptor antagonist modulates the early phase of liver regeneration after partial hepatectomy in mice.

Authors:  Antonino Sgroi; Carmen Gonelle-Gispert; Philippe Morel; Reto Marc Baertschiger; Nadja Niclauss; Gilles Mentha; Pietro Majno; Veronique Serre-Beinier; Leo Buhler
Journal:  PLoS One       Date:  2011-09-27       Impact factor: 3.240

6.  Stimulation of Proliferation and Migration of Mouse Macrophages by Type B CpG-ODNs Is F-Spondin and IL-1Ra Dependent.

Authors:  Tai-An Chen; Chiao-Chun Liao; Yung-Chih Cheng; Yen-Po Chen; Yi-Fan Hsu; Chi-Ming Liang; Shu-Mei Liang
Journal:  PLoS One       Date:  2015-06-04       Impact factor: 3.240

Review 7.  The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis.

Authors:  Megan Yu; Sheng-Feng Tsai; Yu-Min Kuo
Journal:  Int J Mol Sci       Date:  2017-06-13       Impact factor: 5.923

8.  Interleukin-1 Receptor Antagonist Protects Newborn Mice Against Pulmonary Hypertension.

Authors:  Christine B Bui; Magdalena Kolodziej; Emma Lamanna; Kirstin Elgass; Arvind Sehgal; Ina Rudloff; Daryl O Schwenke; Hirotsugu Tsuchimochi; Maurice A G M Kroon; Steven X Cho; Anton Maksimenko; Marian Cholewa; Philip J Berger; Morag J Young; Jane E Bourke; James T Pearson; Marcel F Nold; Claudia A Nold-Petry
Journal:  Front Immunol       Date:  2019-07-11       Impact factor: 7.561
  8 in total

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