Literature DB >> 18281883

Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice.

Jianping Zhou1, Hui Kong, Xiangdong Hua, Ming Xiao, Jiong Ding, Gang Hu.   

Abstract

To investigate the role of astroglial water channel aquaporin-4 (AQP4) in maintaining blood-brain barrier integrity, structure and permeability of the brain microvessels were investigated in adult AQP4 knockout mice. Altered ultrastructure of brain microvessels, including open tight junctions and swollen perivascular astrocytic endfeet, were frequently observed in the AQP4 null mice. Likewise, AQP4 deficiency significantly downregulated expression of glial fibrillary acidic protein in perivascular processes of astrocytes. Furthermore, the horseradish peroxidase analysis demonstrated hyperpermeability of the blood-brain barrier in AQP4 knockout mice. These findings provide direct evidence that AQP4 is essential for the maintenance of blood-brain barrier integrity.

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Year:  2008        PMID： 18281883     DOI： 10.1097/WNR.0b013e3282f2b4eb

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  53 in total

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Review 2.  Aquaporins in cerebrovascular disease: a target for treatment of brain edema?

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Journal:  Cerebrovasc Dis       Date:  2011-04-12       Impact factor: 2.762

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Review 4.  Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain.

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Journal:  Neurochem Res       Date:  2017-06-20       Impact factor: 3.996

5.  Coverage of blood vessels by astrocytic endfeet is reduced in major depressive disorder.

Authors:  Grazyna Rajkowska; Jonathan Hughes; Craig A Stockmeier; Jose Javier Miguel-Hidalgo; Dorota Maciag
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6.  A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

Authors:  Jeffrey J Iliff; Minghuan Wang; Yonghong Liao; Benjamin A Plogg; Weiguo Peng; Georg A Gundersen; Helene Benveniste; G Edward Vates; Rashid Deane; Steven A Goldman; Erlend A Nagelhus; Maiken Nedergaard
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7.  Perspectives on neonatal hypoxia/ischemia-induced edema formation.

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8.  Sporadic obstructive hydrocephalus in Aqp4 null mice.

Authors:  Xuechao Feng; Marios C Papadopoulos; Jun Liu; Lihua Li; Di Zhang; Hongguo Zhang; A S Verkman; Tonghui Ma
Journal:  J Neurosci Res       Date:  2009-04       Impact factor: 4.164

9.  Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus.

Authors:  Brian K Owler; Tom Pitham; Dongwei Wang
Journal:  Cerebrospinal Fluid Res       Date:  2010-09-22

10.  AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury.

Authors:  Efthimios Dardiotis; Konstantinos Paterakis; Georgios Tsivgoulis; Magdalini Tsintou; Georgios F Hadjigeorgiou; Maria Dardioti; Savas Grigoriadis; Constantina Simeonidou; Apostolos Komnos; Eftychia Kapsalaki; Kostas Fountas; Georgios M Hadjigeorgiou
Journal:  J Neurotrauma       Date:  2014-10-10       Impact factor: 5.269
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