| Literature DB >> 18281151 |
Shin Nishio1, Kimio Ushijima, Naotake Tsuda, Shuji Takemoto, Kouichiro Kawano, Tomohiko Yamaguchi, Naoyo Nishida, Tatsuyuki Kakuma, Hitoshi Tsuda, Takahiro Kasamatsu, Yuko Sasajima, Masayoshi Kage, Michihiko Kuwano, Toshiharu Kamura.
Abstract
Cap43 is a nickel- and calcium-inducible gene that plays important roles in the primary growth of malignant tumors, as well as in invasion and metastasis, most likely through its ability to induce cellular differentiation. This study investigated associations of Cap43 expression with angiogenesis and other clinicopathological factors in cervical adenocarcinoma. The clinical records of 100 women who underwent surgery for cervical adenocarcinoma were reviewed retrospectively. Microvessel density and the expression of Cap43 and VEGF in the surgical specimens were evaluated immunohistochemically. The Cap43 expression level was significantly associated with angiogenesis, tumor diameter, stromal invasion, lymphovascular space invasion, lymph node metastasis, and histopathological differentiation. Kaplan-Meier analysis showed a significant association between the Cap43 expression level and survival: high Cap43 expression was related to poor survival. Our results suggest that increased expression of Cap43 is associated with angiogenesis and may be a poor prognostic indicator in women with cervical adenocarcinoma.Entities:
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Year: 2008 PMID： 18281151 DOI： 10.1016/j.canlet.2008.01.020
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679