| Literature DB >> 18280574 |
Bhanu P Pappu1, Pornpimon Angkasekwinai, Chen Dong.
Abstract
Interleukin 17 (IL-17) family consists of six cytokines in mammals. Among them, IL-17 and IL-17F are expressed by a novel subset of CD4+ helper T (Th) cells and play critical function in inflammation and autoimmunity. On the other hand, IL-17E, also called IL-25, has been associated with allergic responses. Here we summarize recent work by us as well as other investigators in understanding the regulation and function of these three cytokines. From these studies, IL-17 family cytokines may serve as novel targets for pharmaceutical intervention of immune and inflammatory diseases.Entities:
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Year: 2008 PMID： 18280574 PMCID： PMC2276145 DOI： 10.1016/j.pharmthera.2007.12.003
Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310