| Literature DB >> 18280470 |
Tiina Immonen1, Anniina Alakuijala, Marjo Hytönen, Kirsi Sainio, Dmitry Poteryaev, Mart Saarma, Michael Pasternack, Hannu Sariola.
Abstract
The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyramidal neurons. The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor.Entities:
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Year: 2008 PMID： 18280470 DOI： 10.1016/j.expneurol.2007.12.018
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330