OBJECTIVES: To investigate the influence of androgen deprivation therapy (ADT) in men with nonmetastatic prostate cancer. METHODS: We conducted a 2-year controlled, prospective study. Twenty-three men on 6 months or longer of ADT (chronic), 12 men on less than 6 months of ADT (acute), and 13 men not on ADT (healthy controls or prostate cancer patients not on ADT) were studied. We used validated, objective tests for physical and visual-motor function and dual X-ray absorptiometry for body composition at baseline and at 24 months. RESULTS: We found the baseline percentage of body fat increased and baseline percentage of lean mass decreased with duration of ADT (P <0.002 across groups for both). After 24 months, men on chronic ADT had significant declines in lean body mass percentage (P = 0.058) and increases in body fat percentage (P = 0.029). Men on acute ADT had smaller but still significant differences in body composition at baseline and similar trends at 24 months. At baseline, men on chronic ADT had longer chair rise times than men on no ADT (P = 0.073) or acute ADT (P = 0.035). Four-meter walk velocities at 24 months were slower in men on acute (P = 0.006) and chronic ADT (P <0.001). CONCLUSIONS: Declines in lean body mass and increases in body fat percentage over 2 years are observed in men on ADT. Lower body physical function performance is reduced in men on chronic ADT. Changes in body composition and physical function should be considered in men on long-term ADT.
RCT Entities:
OBJECTIVES: To investigate the influence of androgen deprivation therapy (ADT) in men with nonmetastatic prostate cancer. METHODS: We conducted a 2-year controlled, prospective study. Twenty-three men on 6 months or longer of ADT (chronic), 12 men on less than 6 months of ADT (acute), and 13 men not on ADT (healthy controls or prostate cancerpatients not on ADT) were studied. We used validated, objective tests for physical and visual-motor function and dual X-ray absorptiometry for body composition at baseline and at 24 months. RESULTS: We found the baseline percentage of body fat increased and baseline percentage of lean mass decreased with duration of ADT (P <0.002 across groups for both). After 24 months, men on chronic ADT had significant declines in lean body mass percentage (P = 0.058) and increases in body fat percentage (P = 0.029). Men on acute ADT had smaller but still significant differences in body composition at baseline and similar trends at 24 months. At baseline, men on chronic ADT had longer chair rise times than men on no ADT (P = 0.073) or acute ADT (P = 0.035). Four-meter walk velocities at 24 months were slower in men on acute (P = 0.006) and chronic ADT (P <0.001). CONCLUSIONS:Declines in lean body mass and increases in body fat percentage over 2 years are observed in men on ADT. Lower body physical function performance is reduced in men on chronic ADT. Changes in body composition and physical function should be considered in men on long-term ADT.
Authors: Erik D Hanson; Mohamdod Alzer; Jackson Carver; Cameron K Stopforth; Alexander R Lucas; Young E Whang; Matthew I Milowsky; David B Bartlett; Michael R Harrison; Rhonda L Bitting; Allison M Deal; Lee Stoner; A C Hackney; Claudio L Battaglini Journal: Prostate Cancer Prostatic Dis Date: 2022-03-19 Impact factor: 5.554
Authors: Erik D Hanson; Andrew K Sheaff; Suchi Sood; Lei Ma; Jack D Francis; Andrew P Goldberg; Ben F Hurley Journal: J Gerontol A Biol Sci Med Sci Date: 2012-10-22 Impact factor: 6.053
Authors: Cristiana Reis; Sami Liberman; Antonio Carlos Pompeo; Miguel Srougi; Alfredo Halpern; Wilson Jacob Filho Journal: Clinics (Sao Paulo) Date: 2009 Impact factor: 2.365
Authors: Brian D Gonzalez; Heather S L Jim; Brent J Small; Steven K Sutton; Mayer N Fishman; Babu Zachariah; Randy V Heysek; Paul B Jacobsen Journal: Support Care Cancer Date: 2015-11-13 Impact factor: 3.359