Literature DB >> 18279851

The status and role of ErbB receptors in human cancer.

I Uberall1, Z Kolár, R Trojanec, J Berkovcová, M Hajdúch.   

Abstract

Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands, which can lead to developmental defects and have been associated with many types of cancers.

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Year:  2008        PMID： 18279851     DOI： 10.1016/j.yexmp.2007.12.002

Source DB:  PubMed          Journal:  Exp Mol Pathol        ISSN： 0014-4800            Impact factor:   3.362


  30 in total

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