Martin R Pollak1. 1. Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. mpollak@rics.bwh.harvard.edu
Abstract
PURPOSE OF REVIEW: Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children. RECENT FINDINGS: The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis. SUMMARY: A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.
PURPOSE OF REVIEW: Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children. RECENT FINDINGS: The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis. SUMMARY: A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.
Authors: Marcus G Pezzolesi; Jan Skupien; Josyf C Mychaleckyj; James H Warram; Andrzej S Krolewski Journal: Semin Nephrol Date: 2010-03 Impact factor: 5.299