OBJECTIVE: The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophilia patients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. MATERIAL AND METHODS: From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophilia patients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. RESULTS: HCV infection is common among hemophilia patients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophilia patients. In 41% of hemophilia patients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophilia patients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele - 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05). CONCLUSIONS: Natural clearance of HCV infection is frequently found in hemophilia patients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophilia patients.
OBJECTIVE: The objective of this study was to investigate the prevalence of HCV (hepatitis C virus) infection in hemophiliapatients in Latvia and to analyze association between natural clearance of HCV and human leukocyte antigen (HLA) class II genes. MATERIAL AND METHODS: From 61 hemophilic patients participating in this study, 38 were adults and 23 were pediatric patients younger than 18 years. To analyze association between HLA class II alleles and natural clearance of HCV, the gene frequency was compared in hemophiliapatients group and the control group of 60 healthy subjects, all men. Serum HCV RNA was qualitatively determined and HLA class II alleles were identified by polymerase chain reaction (PCR) method. RESULTS:HCV infection is common among hemophiliapatients in Latvia. Antibodies to HCV were found in 45 of 61 (74%) hemophiliapatients. In 41% of hemophiliapatients (18 of 44), HCV infection resolved spontaneously. Children cleared HCV more frequently than adults (7 of 11 comparing to 11 of 33, respectively; OR=3.50; P<0.05). The frequency difference was found to be statistically significant when comparing HLA alleles distribution in the sample of hemophiliapatients who naturally cleared HCV (n=18) and in the control group (n=60) (corresponding frequency of HLA-DRB1*07 allele - 4 (11.11%) and 9 (1.67%); OR=7.38; P<0.05). CONCLUSIONS: Natural clearance of HCV infection is frequently found in hemophiliapatients in Latvia. Children are more likely to clear virus naturally than adults. There is an association between natural clearance of HCV and HLA allele DRB1*07 in hemophiliapatients.
Authors: Doa'a A Saleh; Fatma M Shebl; Samer S El-Kamary; Laurence S Magder; Alif Allam; Mohamed Abdel-Hamid; Nabiel Mikhail; Mohamed Hashem; Soraya Sharaf; Sonia K Stoszek; G Thomas Strickland Journal: Trans R Soc Trop Med Hyg Date: 2010-02-12 Impact factor: 2.184
Authors: Claudia A Checa Cabot; Sonia K Stoszek; Jorge Quarleri; Marcelo H Losso; Silvina Ivalo; Mario F Peixoto; José H Pilotto; Horacio Salomon; Leon C Sidi; Jennifer S Read Journal: J Pediatric Infect Dis Soc Date: 2012-10-11 Impact factor: 3.164
Authors: Tiago Pereira Guedes; Mónica Garrido; Ricardo Kuttner Magalhães; Teresa Moreira; Marta Rocha; Luís Maia; José Manuel Ferreira; Sara Morais; Isabel Pedroto Journal: GE Port J Gastroenterol Date: 2020-09-29