Literature DB >> 18277001

Griseusin D, a new pyranonaphthoquinone derivative from a alkaphilic Nocardiopsis sp.

Yi-Qing Li1, Ming-Gang Li, Wei Li, Jiang-Yuan Zhao, Zhang-Gui Ding, Xiao-Long Cui, Meng-Liang Wen.   

Abstract

A new pyranonaphthoquinone antibiotic, griseusin D (1) was isolated from the cultural fluid of the alkaphilic Nocardiopsis sp. The structure was determined as 5'-one-4-hydroxy-12-methoxygriseusin by spectroscopic methods, comparison with reported data and single-crystal X-ray analysis. 1 displayed strong cytotoxicity against human leukemia cells (HL60) and modest cytotoxicity against human lung adenocarcinoma cell lines (AGZY) with IC(50) values of 0.23 and 19.6 microg/ml, respectively. It also exhibited weak antifungal activity against Alternaria alternate with MIC of 140 microg/ml.

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Year:  2007        PMID： 18277001     DOI： 10.1038/ja.2007.100

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  12 in total

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