Literature DB >> 18276140

N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.

Gui-Bai Liang1, Xiaoxia Qian, Dennis Feng, Michael Fisher, Tami Crumley, Sandra J Darkin-Rattray, Paula M Dulski, Anne Gurnett, Penny Sue Leavitt, Paul A Liberator, Andrew S Misura, Samantha Samaras, Tamas Tamas, Dennis M Schmatz, Matthew Wyvratt, Tesfaye Biftu.   

Abstract

Diaryl-(4-piperidinyl)-pyrrole derivatives bearing cyclic amine substituents have been synthesized and evaluated as anticoccidial agents. Improvements in potency of Et-PKG inhibition, such as azetidine derivative 3a, and broad spectrum anticoccidial activities in feed, such as morpholine derivative 8c, have been achieved.

Entities:  

Mesh:

Substances:

Year:  2008        PMID: 18276140     DOI: 10.1016/j.bmcl.2008.01.104

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives.

Authors:  Moumen S Kamel; Amany Belal; Moustafa O Aboelez; E Kh Shokr; H Abdel-Ghany; Hany S Mansour; Ahmed M Shawky; Mahmoud Abd El Aleem Ali Ali El-Remaily
Journal:  Molecules       Date:  2022-03-23       Impact factor: 4.411

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.