| Literature DB >> 18276138 |
James G Douglass1, J Bryan deCamp, Emilee H Fulcher, William Jones, Sanjoy Mahanty, Anna Morgan, Dima Smirnov, José L Boyer, Paul S Watson.
Abstract
Modified adenosine derivatives may lead to the development of P2Y(12) antagonists that are potent, selective, and bind reversibly to the receptor. Analogues of 2',3'-trans-styryl acetal-N6-ureido-adenosine monophosphate were prepared by modification of the 5'-position. The resulting analogues were tested for P2Y(12) antagonism in a platelet aggregation assay.Entities:
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Year: 2008 PMID： 18276138 DOI： 10.1016/j.bmcl.2008.01.038
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823