Literature DB >> 18276135

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium.

Jeong Hoon Yoon1, Hyo Jin Lim, Hwa Jin Lee, Hee-Doo Kim, Raok Jeon, Jae-Ha Ryu.   

Abstract

Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC(50) values: 0.47, 11.2, 136.5 microM, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappaB through the inhibition of LPS-induced I-kappaB-alpha degradation in microglia.

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Year:  2008        PMID： 18276135     DOI： 10.1016/j.bmcl.2007.12.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

1.  Xanthatin induces cell cycle arrest at G2/M checkpoint and apoptosis via disrupting NF-κB pathway in A549 non-small-cell lung cancer cells.

Authors:  Lei Zhang; Junshan Ruan; Linggeng Yan; Weidong Li; Yu Wu; Li Tao; Feng Zhang; Shizhong Zheng; Aiyun Wang; Yin Lu
Journal:  Molecules       Date:  2012-03-26       Impact factor: 4.411

2.  Phytotoxic effects and a phytotoxin from the invasive plant Xanthium italicum Moretti.

Authors:  Hua Shao; Xiaoli Huang; Xiaoyi Wei; Chi Zhang
Journal:  Molecules       Date:  2012-04-02       Impact factor: 4.411

3.  Volatiles Profiling, Allelopathic Activity, and Antioxidant Potentiality of Xanthium Strumarium Leaves Essential Oil from Egypt: Evidence from Chemometrics Analysis.

Authors:  Ahmed Abd El-Gawad; Abdelsamed Elshamy; Abd El-Nasser El Gendy; Ahmed Gaara; Abdulaziz Assaeed
Journal:  Molecules       Date:  2019-02-07       Impact factor: 4.411

4.  Characteristics of the completed chloroplast genome sequence of Xanthium spinosum: comparative analyses, identification of mutational hotspots and phylogenetic implications.

Authors:  Gurusamy Raman; Kyu Tae Park; Joo-Hwan Kim; SeonJoo Park
Journal:  BMC Genomics       Date:  2020-12-02       Impact factor: 3.969

5.  Comparative Transcriptome Analysis Identifies Putative Genes Involved in the Biosynthesis of Xanthanolides in Xanthium strumarium L.

Authors:  Yuanjun Li; Junbo Gou; Fangfang Chen; Changfu Li; Yansheng Zhang
Journal:  Front Plant Sci       Date:  2016-08-30       Impact factor: 5.753

6.  Rapid Characterization and Discovery of Chemical Markers for Discrimination of Xanthii Fructus by Gas Chromatography Coupled to Mass Spectrometry.

Authors:  Hayoung Kim; Youngae Jung; So Hyeon Jeon; Geum-Sook Hwang; Yun Gyong Ahn
Journal:  Molecules       Date:  2019-11-11       Impact factor: 4.411

7.  Optimization of xanthatin extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties.

Authors:  M Romero; M Zanuy; E Rosell; M Cascante; J Piulats; M Font-Bardia; J Balzarini; E De Clerq; M D Pujol
Journal:  Eur J Med Chem       Date:  2014-12-01       Impact factor: 6.514
  7 in total

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