Literature DB >> 1827611

Global ischemia induces NMDA receptor-mediated c-fos expression in neurons resistant to injury in gerbil hippocampus.

Y Uemura1, N W Kowall, M F Beal.   

Abstract

The induction of c-fos protein-like immunoreactivity (CFPLI) was examined in the hippocampus of gerbils at several time points after transient global ischemia. c-Fos protein induction was largely confined to the dentate gyrus, CA3 and CA4 regions from 2 to 8 h after transient bilateral carotid occlusion. Little CFPLI was seen in the CA1 subfield, which is disproportionately sensitive to injury after global ischemia. c-Fos induction was completely blocked by pretreatment with MK-801 (3 mg/kg). Our results show that c-fos expression after global ischemia is NMDA receptor mediated, and mainly found in hippocampal neurons resistant to ischemic injury.

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Year:  1991        PMID： 1827611     DOI： 10.1016/0006-8993(91)91589-s

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  9 in total

1.  At least three neurotransmitter systems mediate a stress-induced increase in c-fos mRNA in different rat brain areas.

Authors:  E Bozas; N Tritos; H Phillipidis; F Stylianopoulou
Journal:  Cell Mol Neurobiol       Date:  1997-04       Impact factor: 5.046

2.  MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia.

Authors:  A Alessandrini; S Namura; M A Moskowitz; J V Bonventre
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

3.  K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.

Authors:  C Heurteaux; V Bertaina; C Widmann; M Lazdunski
Journal:  Proc Natl Acad Sci U S A       Date:  1993-10-15       Impact factor: 11.205

4.  Transient spinal cord ischemia in rat: the time course of spinal FOS protein expression and the effect of intraischemic hypothermia (27 degrees C).

Authors:  L C Yang; J Orendacova; V Wang; T Ishikawa; T L Yaksh; M Marsala
Journal:  Cell Mol Neurobiol       Date:  2000-06       Impact factor: 5.046

5.  HuR function and translational state analysis following global brain ischemia and reperfusion.

Authors:  Jeffrey J Szymanski; Haihui Wang; Jill T Jamison; Donald J DeGracia
Journal:  Transl Stroke Res       Date:  2013-08-02       Impact factor: 6.829

6.  Opioid use affects antioxidant activity and purine metabolism: preliminary results.

Authors:  Paolo Mannelli; Ashwin Patkar; Steve Rozen; Wayne Matson; Ranga Krishnan; Rima Kaddurah-Daouk
Journal:  Hum Psychopharmacol       Date:  2009-12       Impact factor: 1.672

7.  Reduction of posttraumatic transneuronal "early gene" activation and dendritic atrophy by the N-methyl-D-aspartate receptor antagonist MK-801.

Authors:  R Nitsch; M Frotscher
Journal:  Proc Natl Acad Sci U S A       Date:  1992-06-01       Impact factor: 11.205

8.  Induction of FOS and JUN proteins after focal ischemia in the rat: differential effect of the N-methyl-D-aspartate receptor antagonist MK-801.

Authors:  P Gass; M Spranger; T Herdegen; R Bravo; P Köck; W Hacke; M Kiessling
Journal:  Acta Neuropathol       Date:  1992       Impact factor: 17.088

9.  Variable response of the Mongolian gerbil to unilateral carotid occlusion: magnetic resonance imaging and neuropathological characterization.

Authors:  G P Pelliccioli; C Gambelunghe; P F Ottaviano; S Iannaccone; M V Ambrosini
Journal:  Ital J Neurol Sci       Date:  1995-11
  9 in total

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