| Literature DB >> 18275845 |
Srujana Rayalam1, Mary Anne Della-Fera, Paul A Krieg, Christopher M Cox, Allan Robins, Clifton A Baile.
Abstract
Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.Entities:
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Year: 2008 PMID： 18275845 DOI： 10.1016/j.bbrc.2008.02.008
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575