Literature DB >> 1827558

LHRH analogues do not protect the germinal epithelium during chemotherapy. An experimental animal investigation.

I Papadopoulos1.   

Abstract

The protective effect of Decapeptyl, a D-Trp6-LHRH analogue, on the germinal epithelium of rats during chemotherapy was examined in an experimental animal study. Four groups were formed consisting of 15 (groups A and B) and 20 (groups C and D) Sprague-Dawley rats, respectively. The animals were treated as follows: group A (control group) was given 0.9% NaCl i.m.; group B (LHRH group) D-Trp6-LHRH analogue (Decapeptyl); group C (LHRH + chemotherapy group) Decapeptyl + cyclophosphamide; group D (chemotherapy group) cyclophosphamide. The gonads were removed before therapy was initiated and on days 13, 52, and 182 after treatment and examined histologically. In addition, follicle-stimulating hormone (FSH) levels in the serum, a sensitive indicator of tubular damage, were determined. The most damaging effects of chemotherapy on histology and hormone levels were observed in the animals in group C, which were additionally treated with LHRH analogues. Therefore, it is not possible to protect the germinal epithelium of the rat with LHRH analogues during chemotherapy.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1827558     DOI： 10.1007/bf00294018

Source DB:  PubMed          Journal:  Urol Res        ISSN： 0300-5623


  8 in total

1.  Sterility and testicular atrophy related to cyclophosphamide therapy.

Authors:  K F Fairley; J U Barrie; W Johnson
Journal:  Lancet       Date:  1972-03-11       Impact factor: 79.321

2.  [Effect of "cyclophosphamide" and "procarbacine" on the seminiferous epithelium in the rat].

Authors:  W Hilscher; P Reichelt
Journal:  Beitr Pathol Anat       Date:  1968

Review 3.  ["Environment and fertility". A contribution to the sensitivity of male germ cells to environmental pollutants].

Authors:  W Hilscher
Journal:  Z Hautkr       Date:  1985-07-01

4.  Protection from cyclophosphamide-induced testicular damage with an analogue of gonadotropin-releasing hormone.

Authors:  L M Glode; J Robinson; S F Gould
Journal:  Lancet       Date:  1981-05-23       Impact factor: 79.321

5.  [Animal experiment studies on improving ischemia tolerance of the testis].

Authors:  R Schwaiger; C Stief; M Ziegler
Journal:  Urologe A       Date:  1986-05       Impact factor: 0.639

Review 6.  The effects of cancer and cancer therapy on male fertility.

Authors:  J V Thachil; M A Jewett; W D Rider
Journal:  J Urol       Date:  1981-08       Impact factor: 7.450

7.  D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons.

Authors:  R W Lewis; K J Dowling; A V Schally
Journal:  Proc Natl Acad Sci U S A       Date:  1985-05       Impact factor: 11.205

8.  Cyclical combination chemotherapy and gonadal function. Retrospective study in males.

Authors:  R M Chapman; S B Sutcliffe; L H Rees; C R Edwards; J S Malpas
Journal:  Lancet       Date:  1979-02-10       Impact factor: 79.321
  8 in total
  2 in total

1.  Clomiphene citrate reduces procarbazine-induced sterility in a rat model.

Authors:  R Weissenberg; M Lahav; P Raanani; R Singer; A Regev; M Sagiv; S Giler; E Theodor
Journal:  Br J Cancer       Date:  1995-01       Impact factor: 7.640

2.  Bone marrow examination in newly diagnosed Hodgkin's disease: current practice in the United Kingdom.

Authors:  M R Howard; P R Taylor; H H Lucraft; M J Taylor; S J Proctor
Journal:  Br J Cancer       Date:  1995-01       Impact factor: 7.640
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.