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Literature DB >> 18272668

HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.

Najat Mahdi¹, Khadija Al-Ola, Abeer M Al-Subaie, Muhallab E Ali, Zaid Al-Irhayim, A Qader Al-Irhayim, Wassim Y Almawi.

Abstract

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class II haplotypes influence VOC risk.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18272668 PMCID： PMC2292664 DOI： 10.1128/CVI.00425-07

Source DB: PubMed Journal: Clin Vaccine Immunol ISSN： 1556-679X

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References

23 in total

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HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.

Review 1. Sickle cell disease: a multigenic perspective of a single gene disorder.

2. Evidence for HLA-related susceptibility for stroke in children with sickle cell disease.

3. Sickle cell disease in Bahrain: coexistence and interaction with glucose-6-phosphate dehydrogenase (G6PD) deficiency.

4. HLA-DRB1 alleles in Hb SS patients with avascular necrosis of the femoral head.

Review 5. Pain management in children with sickle cell disease.

6. Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs.

7. Impaired vasodilation by red blood cells in sickle cell disease.

8. Distinct HLA associations by stroke subtype in children with sickle cell anemia.

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