| Literature DB >> 18272374 |
Julien Chapuis1, Didier Hannequin, Florence Pasquier, Peter Bentham, Alexis Brice, Isabelle Leber, Thierry Frebourg, Jean-François Deleuze, Emmanuelle Cousin, Uma Thaker, Philippe Amouyel, David Mann, Corinne Lendon, Dominique Campion, Jean-Charles Lambert.
Abstract
The first genome-wide association in Alzheimer's disease (AD) suggested that the GAB2 gene rs2373115 polymorphism may be a strong risk factor in APOE varepsilon4-carriers. We failed to detect an association of rs2373115 with the risk of developing AD in three populations (totalling 1406 controls and 1749 AD cases) whatever the APOE status, even if we observed a slight tendency for an increase of the GG genotype (OR (GG versus GT+TT)=1.3, 95% CI 1.0-1.6, p=0.09) and the G allele frequency (OR=1.3, 95%CI 1.0-1.6, p=0.05) in varepsilon4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD.Entities:
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Year: 2008 PMID： 18272374 DOI： 10.1016/j.nbd.2007.12.006
Source DB: PubMed Journal: Neurobiol Dis ISSN： 0969-9961 Impact factor: 5.996