Literature DB >> 18272373

The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

Junfeng Huang1, Crina M Orac, Susan McKay, Dennis B McKay, Stephen C Bergmeier.   

Abstract

Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki-Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki-Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.

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Year:  2008        PMID： 18272373     DOI： 10.1016/j.bmc.2008.01.050

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors.

Authors:  Brandon J Henderson; Ryan E Pavlovicz; Jerad D Allen; Tatiana F González-Cestari; Crina M Orac; Andrew B Bonnell; Michael X Zhu; R Thomas Boyd; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  J Pharmacol Exp Ther       Date:  2010-06-15       Impact factor: 4.030

2.  3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors.

Authors:  Brandon J Henderson; Crina M Orac; Iwona Maciagiewicz; Stephen C Bergmeier; Dennis B McKay
Journal:  Bioorg Med Chem Lett       Date:  2011-11-20       Impact factor: 2.823

3.  Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery.

Authors:  Tatiana F González-Cestari; Brandon J Henderson; Ryan E Pavlovicz; Susan B McKay; Raed A El-Hajj; Aravinda B Pulipaka; Crina M Orac; Damon D Reed; R Thomas Boyd; Michael X Zhu; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  J Pharmacol Exp Ther       Date:  2008-11-04       Impact factor: 4.030

4.  Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors.

Authors:  Brandon J Henderson; Tatiana F González-Cestari; Bitna Yi; Ryan E Pavlovicz; R Thomas Boyd; Chenglong Li; Stephen C Bergmeier; Dennis B McKay
Journal:  ACS Chem Neurosci       Date:  2012-05-25       Impact factor: 4.418
  4 in total

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