Literature DB >> 18272370

Design, synthesis, biological evaluation and docking studies of pterostilbene analogs inside PPARalpha.

Cassia S Mizuno1, Guoyi Ma, Shabana Khan, Akshay Patny, Mitchell A Avery, Agnes M Rimando.   

Abstract

Pterostilbene, a naturally occurring analog of resveratrol, has previously shown PPARalpha activation in H4IIEC3 cells and was found to decrease cholesterol levels in animals. In this study, analogs of pterostilbene were synthesized and their ability to activate PPARalpha was investigated. Among analogs that was synthesized (E)-4-(3,5-dimethoxystyryl)phenyl dihydrogen phosphate showed activity higher than pterostilbene and control drug ciprofibrate. Docking of the stilbenes inside PPARalpha showed the presence of important hydrogen bond interactions for PPARalpha activation.

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Year:  2008        PMID： 18272370     DOI： 10.1016/j.bmc.2008.01.051

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer.

Authors:  Shiby Paul; Cassia S Mizuno; Hong Jin Lee; Xi Zheng; Sarah Chajkowisk; John M Rimoldi; Allan Conney; Nanjoo Suh; Agnes M Rimando
Journal:  Eur J Med Chem       Date:  2010-05-15       Impact factor: 6.514

Review 2.  PPAR-α as a key nutritional and environmental sensor for metabolic adaptation.

Authors:  Alejandra V Contreras; Nimbe Torres; Armando R Tovar
Journal:  Adv Nutr       Date:  2013-07-01       Impact factor: 8.701

3.  Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets.

Authors:  Hao Zhang; Yanan Chen; Yue Li; Peilu Jia; Shuli Ji; Yueping Chen; Tian Wang
Journal:  J Anim Sci       Date:  2020-10-01       Impact factor: 3.159

4.  Analysis of safety from a human clinical trial with pterostilbene.

Authors:  Daniel M Riche; Corey L McEwen; Krista D Riche; Justin J Sherman; Marion R Wofford; David Deschamp; Michael Griswold
Journal:  J Toxicol       Date:  2013-02-04

5.  Synthesis and antiproliferative activity of pterostilbene and 3′-methoxy pterostilbene Mannich base derivatives against Hela cells.

Authors:  Chongyang Liu; Linpei Dong; Shengchun Wang; Qiuan Wang
Journal:  Mol Divers       Date:  2015-07-11       Impact factor: 2.943

Review 6.  Synthetic approaches toward stilbenes and their related structures.

Authors:  Zulfiqar Ali Khan; Ahsan Iqbal; Sohail Anjum Shahzad
Journal:  Mol Divers       Date:  2017-04-21       Impact factor: 2.943

7.  Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer.

Authors:  Kun Li; Steven J Dias; Agnes M Rimando; Swati Dhar; Cassia S Mizuno; Alan D Penman; Jack R Lewin; Anait S Levenson
Journal:  PLoS One       Date:  2013-03-01       Impact factor: 3.240

8.  Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders.

Authors:  Xiaozheng Dou; Dinesh Nath; Henry Shin; Elmar Nurmemmedov; Philip C Bourne; Jian-Xing Ma; Adam S Duerfeldt
Journal:  J Med Chem       Date:  2020-03-10       Impact factor: 8.039
  8 in total

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