Literature DB >> 18270535

Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation.

Ling Yang1, Ying Wu, Huaixin Li, Zhijie Yu, Xin Li, Yong Liu, Xu Lin, Yan Chen.   

Abstract

Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10 kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings.

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Year:  2008        PMID： 18270535     DOI： 10.1038/ejhg.2008.8

Source DB:  PubMed          Journal:  Eur J Hum Genet        ISSN： 1018-4813            Impact factor:   4.246


  9 in total

1.  A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.

Authors:  Ranjan Deka; Ling Xu; Prodipto Pal; Palanitina T Toelupe; Tuiasina S Laumoli; Huifeng Xi; Ge Zhang; Daniel E Weeks; Stephen T McGarvey
Journal:  BMC Med Genet       Date:  2009-12-22       Impact factor: 2.103

2.  INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.

Authors:  Ann Chen Wu; Matthew W Gillman; Elsie M Taveras; Augusto A Litonjua
Journal:  Clin Med Pediatr       Date:  2009

3.  INSIG2 variants, dietary patterns and metabolic risk in Samoa.

Authors:  A Baylin; R Deka; J Tuitele; S Viali; D E Weeks; S T McGarvey
Journal:  Eur J Clin Nutr       Date:  2012-09-12       Impact factor: 4.016

4.  Possible role for ENPP1 polymorphism in obesity but not for INSIG2 and PLIN variants.

Authors:  Armand Peeters; Sigri Beckers; An Verrijken; Ilse Mertens; Luc Van Gaal; Wim Van Hul
Journal:  Endocrine       Date:  2009-04-28       Impact factor: 3.633

5.  INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.

Authors:  Matthew E Talbert; Carl D Langefeld; Julie T Ziegler; Steven M Haffner; Jill M Norris; Donald W Bowden
Journal:  Obesity (Silver Spring)       Date:  2009-04-09       Impact factor: 5.002

6.  Association of INSIG2 polymorphism with overweight and LDL in children.

Authors:  Anne-Marie Kaulfers; Ranjan Deka; Lawrence Dolan; Lisa J Martin
Journal:  PLoS One       Date:  2015-01-21       Impact factor: 3.240

7.  The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

Authors:  Jan Bressler; Myriam Fornage; Craig L Hanis; Wen Hong Linda Kao; Cora E Lewis; Ruth McPherson; Robert Dent; Thomas H Mosley; Len A Pennacchio; Eric Boerwinkle
Journal:  BMC Med Genet       Date:  2009-06-12       Impact factor: 2.103

8.  Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.

Authors:  Seongwon Cha; Imhoi Koo; Sun Mi Choi; Byung Lae Park; Kil Soo Kim; Jae-Ryong Kim; Hyoung Doo Shin; Jong Yeol Kim
Journal:  BMC Med Genet       Date:  2009-09-22       Impact factor: 2.103

9.  INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.

Authors:  Kikuko Hotta; Michihiro Nakamura; Yoshio Nakata; Tomoaki Matsuo; Seika Kamohara; Kazuaki Kotani; Ryoya Komatsu; Naoto Itoh; Ikuo Mineo; Jun Wada; Hiroaki Masuzaki; Masato Yoneda; Atsushi Nakajima; Shigeru Miyazaki; Katsuto Tokunaga; Manabu Kawamoto; Tohru Funahashi; Kazuyuki Hamaguchi; Kentaro Yamada; Toshiaki Hanafusa; Shinichi Oikawa; Hironobu Yoshimatsu; Kazuwa Nakao; Toshiie Sakata; Yuji Matsuzawa; Kiyoji Tanaka; Naoyuki Kamatani; Yusuke Nakamura
Journal:  J Hum Genet       Date:  2008-07-10       Impact factor: 3.172
  9 in total

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