Waveform diversity based ultrasound system for hyperthermia treatment of breast cancer.

In this letter, we present a new waveform-diversity-based ultrasound hyperthermia technique for the treatment of breast cancer. Waveform diversity offers a new paradigm for beampattern design. By choosing a proper covariance matrix of the transmitted waveforms under the uniform elemental power constraint, the ultrasound system can provide a focal spot matched to the entire tumor region, and meanwhile, minimize the impact to the surrounding healthy breast tissues. As shown in our 2-D numerical simulations, this method has better acoustic power deposition than the existing methods, and can provide the necessary temperature gradients required for the effective hyperthermia treatment of breast cancer.