Y Fujiyoshi1, T Eimoto. 1. Department of Pathology, Nagoya City University, School of Medicine, Nagoya, Japan. yfuji@med.nagoya-cu.ac.jp
Abstract
AIMS: To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well-differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. METHODS AND RESULTS: 102 SRCCs were categorized into five subtypes according to the predominant cell type in the World Health Organization classification. 38 cases (37.3%) showed focal or diffuse CgA positivity. The positive cells were mostly histiocytoid and eosinophilic SRCC cells and some were classical SRCC cells. Small cell and anaplastic-type SRCC cells were only rarely immunopositive. There was no significant relationship between CgA expression and the extent of invasion or presence of metastasis. However, a significant positive correlation existed between CgA positivity and favourable prognosis, with a tendency for greater positivity to be associated with better overall survival. Multivariate analysis showed expression of CgA to be an independent prognostic factor. CONCLUSION: CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.
AIMS: To investigate neuroendocrine (NE) differentiation in gastric signet ring cell carcinoma (SRCC) using chromogranin A (CgA) as an indicator of a well-differentiated NE phenotype and to determine its relationship to cell type, stage and prognosis. METHODS AND RESULTS: 102 SRCCs were categorized into five subtypes according to the predominant cell type in the World Health Organization classification. 38 cases (37.3%) showed focal or diffuse CgA positivity. The positive cells were mostly histiocytoid and eosinophilic SRCC cells and some were classical SRCC cells. Small cell and anaplastic-type SRCC cells were only rarely immunopositive. There was no significant relationship between CgA expression and the extent of invasion or presence of metastasis. However, a significant positive correlation existed between CgA positivity and favourable prognosis, with a tendency for greater positivity to be associated with better overall survival. Multivariate analysis showed expression of CgA to be an independent prognostic factor. CONCLUSION:CgA expression is restricted to certain tumour cell types and may help to predict prognosis in gastric SRCCs.
Authors: Olga Speck; Weihua Tang; Douglas R Morgan; Pei Fen Kuan; Michael O Meyers; Ricardo L Dominguez; Enrique Martinez; Margaret L Gulley Journal: Appl Immunohistochem Mol Morphol Date: 2015-10