Literature DB >> 18268276

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia.

Brunangelo Falini1, Cristina Mecucci, Giuseppe Saglio, Francesco Lo Coco, Daniela Diverio, Patrick Brown, Fabrizio Pane, Marco Mancini, Maria Paola Martelli, Stefano Pileri, Torsten Haferlach, Claudia Haferlach, Susanne Schnittger.   

Abstract

Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc(+) acute myeloid leukemia) represents one-third of adult AML (50-60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and clinical features. We confirm in 2562 patients with acute myeloid leukemia our previous observation that NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities. Taken together, these findings make NPMc+ acute myeloid leukemia a good candidate for inclusion in the upcoming World Health Organization classification.

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Year:  2008        PMID： 18268276     DOI： 10.3324/haematol.12153

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  16 in total

Review 1.  Nucleophosmin (NPM1) mutations in adult and childhood acute myeloid leukaemia: towards definition of a new leukaemia entity.

Authors:  Rachel Rau; Patrick Brown
Journal:  Hematol Oncol       Date:  2009-12       Impact factor: 5.271

Review 2.  Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.

Authors:  Luca Federici; Brunangelo Falini
Journal:  Protein Sci       Date:  2013-03-18       Impact factor: 6.725

3.  Acute myeloid leukemia with translocation t(3;5): new molecular insights.

Authors:  Florent Dumézy; Aline Renneville; Caroline Mayeur-Rousse; Olivier Nibourel; Elise Labis; Claude Preudhomme
Journal:  Haematologica       Date:  2013-02-12       Impact factor: 9.941

4.  Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.

Authors:  David C Taussig; Jacques Vargaftig; Farideh Miraki-Moud; Emmanuel Griessinger; Kirsty Sharrock; Tina Luke; Debra Lillington; Heather Oakervee; Jamie Cavenagh; Samir G Agrawal; T Andrew Lister; John G Gribben; Dominique Bonnet
Journal:  Blood       Date:  2010-01-06       Impact factor: 22.113

Review 5.  Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications.

Authors:  P Sportoletti; E Varasano; R Rossi; A Mupo; E Tiacci; G Vassiliou; M P Martelli; B Falini
Journal:  Leukemia       Date:  2014-09-02       Impact factor: 11.528

6.  Cuplike nuclei (prominent nuclear invaginations) in acute myeloid leukemia are highly associated with FLT3 internal tandem duplication and NPM1 mutation.

Authors:  Weina Chen; Sergej Konoplev; L Jeffrey Medeiros; Hartmut Koeppen; Vasiliki Leventaki; Saroj Vadhan-Raj; Dan Jones; Hagop M Kantarjian; Brunangelo Falini; Carlos E Bueso-Ramos
Journal:  Cancer       Date:  2009-12-01       Impact factor: 6.860

7.  Cytoplasmic nucleophosmin is not detected in blastic plasmacytoid dendritic cell neoplasm.

Authors:  Fabio Facchetti; Stefano A Pileri; Claudio Agostinelli; Maria Paola Martelli; Marco Paulli; Adriano Venditti; Massimo F Martelli; Brunangelo Falini
Journal:  Haematologica       Date:  2008-12-09       Impact factor: 9.941

Review 8.  Molecular markers in acute myeloid leukaemia.

Authors:  Andrea Kühnl; David Grimwade
Journal:  Int J Hematol       Date:  2012-07-13       Impact factor: 2.490

9.  Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice.

Authors:  George S Vassiliou; Jonathan L Cooper; Roland Rad; Juan Li; Stephen Rice; Anthony Uren; Lena Rad; Peter Ellis; Rob Andrews; Ruby Banerjee; Carolyn Grove; Wei Wang; Pentao Liu; Penny Wright; Mark Arends; Allan Bradley
Journal:  Nat Genet       Date:  2011-03-27       Impact factor: 38.330

10.  NPM1 Gene Type A Mutation in Bulgarian Adults with Acute Myeloid Leukemia: A Single-Institution Study.

Authors:  Gueorgui Balatzenko; Branimir Spassov; Nikolay Stoyanov; Penka Ganeva; Tihomit Dikov; Spiro Konstantinov; Vasil Hrischev; Malina Romanova; Stavri Toshkov; Margarita Guenova
Journal:  Turk J Haematol       Date:  2014-03-05       Impact factor: 1.831
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