| Literature DB >> 1826754 |
T Matsuda1, Y Nakano, T Kanda, H Iwata, A Baba.
Abstract
Subcutaneous injection of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in mice caused hypothermia which was antagonized by pindolol. The hypothermic effect of 8-OH-DPAT was pronounced in female than in male mice. The sex difference in the hypothermic effect was also observed after pretreatment with proadifen. The hypothermic effect of 8-OH-DPAT was attenuated by ovariectomy. In the ovariectomized mice, the effect of 8-OH-DPAT on rectal temperature was enhanced by chronic estradiol and the enhancement was blocked by simultaneous administration of testosterone. In male mice the hypothermic effect of 8-OH-DPAT was enhanced by castration. These results suggest that gonadal hormones affect the 5-HT1A receptor-mediated response.Entities:
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Year: 1991 PMID： 1826754 DOI： 10.1016/0024-3205(91)90122-r
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037