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Literature DB >> 182675

Effect of polymyxin on the ultrastructure of the outer membrane of wild-type and polymyxin-resistant strain of Salmonella.

Abstract

The effect of polymyxin on two sets of Salmonella mutants was studied by thin-section and scanning electron microscopy. Polymyxin (in increasing concentrations, starting just below bactericidal effect) caused the appearance of the previously described rodlike projections on the cell surface of wild-type (smooth, polymyxin-sensitive) bacteria. These projections seemed to involve the outer membrane of the cell wall. In rough mutants, which are deficient in lipopolysaccharide, the projections were much smaller and flat. Higher concentrations of polymyxin were required to produce morphological effects in polyxmin-resistant mutants of both smooth and rough forms. Furthermore, in these mutants polymyxin caused vesicle-like bulging of the total outer membrane quite different in appearance from the rodlike projections of the wild type.

Entities: Chemical

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Year: 1976 PMID： 182675 PMCID： PMC232936 DOI： 10.1128/jb.127.3.1400-1407.1976

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

19 in total

1. Cytological aspects of antimicrobial antibiosis. I. Cytological changes associated with the exposure of Escherichia coli to colistin sulfate.

Authors: G B Chapman
Journal: J Bacteriol Date: 1962-07 Impact factor: 3.490

10. Isolation of lipopolysaccharides and the effect of polymyxin B on the outer membrane of Corynebacterium autotrophicum.

Authors: J Wiegel; F Mayer
Journal: Arch Microbiol Date: 1978-07 Impact factor: 2.552

Effect of polymyxin on the ultrastructure of the outer membrane of wild-type and polymyxin-resistant strain of Salmonella.

1. Cytological aspects of antimicrobial antibiosis. I. Cytological changes associated with the exposure of Escherichia coli to colistin sulfate.

2. The release of soluble constituents from washed cells of Pseudomonas aeruginosa by the action of polymyxin.

3. Electron microscopy of effect of polymyxin on Escherichia coli lipopolysaccharide.

4. The morphologic structure of isolated bacterial lipopolysaccharide.

5. Cytological changes of Escherichia coli caused by polymyxin E.

6. Morphological and physiological investigations on the action of polymyxin B on Escherichia coli.

7. Electron microscopic studies on mode of action of polymyxin.

8. Electron microscopy of lipids and membranes.

9. Repetitive sequences in the murein-lipoprotein of the cell wall of Escherichia coli.

10. Effect of polymyxin on the bacteriophage receptors of the cell walls of gram-negative bacteria.

1. Decreased binding of polymyxin by polymyxin-resistant mutants of Salmonella typhimurium.

2. Polymyxin B-penicillin antagonism in Proteus mirabilis.

3. Bacterial hydrophobicity, an overall parameter for the measurement of adhesion potential to soil particles.

4. Binding and neutralization of bacterial lipopolysaccharide by colistin nonapeptide.

5. Microbiological, biochemical, and electron microscopic characterization of a pectinatus strain.

6. Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility.

7. A nanomechanical study of the effects of colistin on the Klebsiella pneumoniae AJ218 capsule.

8. Bacteroides buccae and related taxa in necrotic root canal infections.

9. Protoplast-like structures formation from two species of Enterobacteriaceae by fosfomycin treatment.

10. Isolation of lipopolysaccharides and the effect of polymyxin B on the outer membrane of Corynebacterium autotrophicum.