Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole.

Literature DB >> 18267360

Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole.

Namdev S Vatmurge¹, Braja G Hazra, Vandana S Pore, Fazal Shirazi, Pradnya S Chavan, Mukund V Deshpande.

Abstract

Synthesis of novel 1,2,3-triazole-linked beta-lactam-bile acid conjugates 17-24 using 1,3-dipolar cycloaddition reaction of azido beta-lactam and terminal alkyne of bile acids in the presence of Cu(I) catalyst (click chemistry) have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and moderate antibacterial activity against all the tested strains.

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18267360 DOI： 10.1016/j.bmcl.2008.01.102

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

19 in total

1. Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles.

Authors: Maryam Mohammadi-Khanaposhtani; Maliheh Safavi; Reyhaneh Sabourian; Mohammad Mahdavi; Mahboobeh Pordeli; Mina Saeedi; Sussan Kabudanian Ardestani; Alireza Foroumadi; Abbas Shafiee; Tahmineh Akbarzadeh
Journal: Mol Divers Date: 2015-07-14 Impact factor: 2.943

2. Design and synthesis of 4,5-diphenyl-imidazol-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic and docking studies.

Authors: Mohammad Sadegh Asgari; Maryam Mohammadi-Khanaposhtani; Zeinab Sharafi; Mohammad Ali Faramarzi; Hossein Rastegar; Ensieh Nasli Esfahani; Fatemeh Bandarian; Parviz Ranjbar Rashidi; Rahmatollah Rahimi; Mahmood Biglar; Mohammad Mahdavi; Bagher Larijani
Journal: Mol Divers Date: 2020-03-18 Impact factor: 2.943

3. Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives.

Authors: Radhakrishnam Raju Ruddarraju; Adharvana Chari Murugulla; Ravindar Kotla; Muni Chandra Babu Tirumalasetty; Rajendra Wudayagiri; Shobha Donthabakthuni; Ravichandar Maroju
Journal: Medchemcomm Date: 2016-10-28 Impact factor: 3.597

Synthesis and antimicrobial activity of beta-lactam-bile acid conjugates linked via triazole.

1. Design, synthesis, in vitro cytotoxic activity evaluation, and apoptosis-induction study of new 9(10H)-acridinone-1,2,3-triazoles.

2. Design and synthesis of 4,5-diphenyl-imidazol-1,2,3-triazole hybrids as new anti-diabetic agents: in vitro α-glucosidase inhibition, kinetic and docking studies.

3. Design, synthesis, anticancer activity and docking studies of theophylline containing 1,2,3-triazoles with variant amide derivatives.

4. 3-(2,4-Dichloro-phen-oxy)-1-(4-meth-oxy-phen-yl)-4-(3-nitro-phen-yl)azetidin-2-one.

5. Advances in synthetic approach to and antifungal activity of triazoles.

6. 1-(4-Meth-oxy-phen-yl)-4-(3-nitro-phen-yl)-3-phen-oxy-azetidin-2-one.

7. Synthesis and evaluation of some new aza-B-homocholestane derivatives as anticancer agents.

Review 8. The application of click chemistry in the synthesis of agents with anticancer activity.

9. Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.

10. Discovery of novel 1,2,3-triazole derivatives as anticancer agents using QSAR and in silico structural modification.