| Literature DB >> 18267111 |
Min-Sook Kang1, Shizuka Hirai, Tsuyoshi Goto, Kayo Kuroyanagi, Joo-Young Lee, Taku Uemura, Yoichiro Ezaki, Nobuyuki Takahashi, Teruo Kawada.
Abstract
Obesity is characterized by an enhanced infiltration of macrophages to adipose tissues, which is closely associated with the low-grade inflammatory state and obesity-related pathologies such as type 2 diabetes and cardiovascular diseases. We showed here that dehydroabietic acid (DAA) is a potent PPARalpha/gamma dual activator. Furthermore, we examined the anti-inflammatory effects of DAA in stimulated macrophages and in the coculture of macrophages and adipocytes. DAA significantly suppressed the production of proinflammatory mediators such as MCP-1, TNF-alpha, and NO in stimulated RAW 264 macrophages and in the coculture of RAW 264 macrophages and 3T3-L1 adipocytes. These results suggest that DAA is a valuable medicinal and food component for improving inflammatory changes associated with obesity-related diabetes.Entities:
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Year: 2008 PMID： 18267111 DOI： 10.1016/j.bbrc.2008.02.002
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575