Literature DB >> 18265382

Minimizing variation due to genotype and environment.

Carmen A Argmann1, Johan Auwerx.   

Abstract

Mouse models are increasingly popular tools to study and characterize the molecular and physiological bases for human diseases. Due to the readily available genetic tools to construct mouse models of complex diseases, the flow of efficient and vigilant mouse phenotyping has now become the bottleneck in mouse functional genomics. This unit addresses the importance of minimizing and defining confounding genetic and environmental sources of variability.

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Mesh：

Year:  2006        PMID： 18265382     DOI： 10.1002/0471142727.mb29a02s73

Source DB:  PubMed          Journal:  Curr Protoc Mol Biol        ISSN： 1934-3647


  4 in total

1.  Salt and acid-base metabolism in claudin-16 knockdown mice: impact for the pathophysiology of FHHNC patients.

Authors:  Nina Himmerkus; Qixian Shan; Boeren Goerke; Jianghui Hou; Daniel A Goodenough; Markus Bleich
Journal:  Am J Physiol Renal Physiol       Date:  2008-09-10

2.  Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.

Authors:  Liliana Menalled; Bassem F El-Khodor; Monica Patry; Mayte Suárez-Fariñas; Samantha J Orenstein; Benjamin Zahasky; Christina Leahy; Vanessa Wheeler; X William Yang; Marcy MacDonald; A Jennifer Morton; Gill Bates; Janet Leeds; Larry Park; David Howland; Ethan Signer; Allan Tobin; Daniela Brunner
Journal:  Neurobiol Dis       Date:  2009-05-21       Impact factor: 5.996

3.  TGR5-mediated bile acid sensing controls glucose homeostasis.

Authors:  Charles Thomas; Antimo Gioiello; Lilia Noriega; Axelle Strehle; Julien Oury; Giovanni Rizzo; Antonio Macchiarulo; Hiroyasu Yamamoto; Chikage Mataki; Mark Pruzanski; Roberto Pellicciari; Johan Auwerx; Kristina Schoonjans
Journal:  Cell Metab       Date:  2009-09       Impact factor: 27.287

4.  TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.

Authors:  Taoufiq Harach; Thijs W H Pols; Mitsunori Nomura; Adriano Maida; Mitsuhiro Watanabe; Johan Auwerx; Kristina Schoonjans
Journal:  Sci Rep       Date:  2012-05-30       Impact factor: 4.379
  4 in total

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