Literature DB >> 18264751

The role of host genetics in the susceptibility for HIV-associated neurocognitive disorders.

Andrew J Levine1, Elyse J Singer, Paul Shapshak.   

Abstract

Despite progress in the treatment of the Human Immunodeficiency virus (HIV), there continues to be a high prevalence of infected individuals who develop neurocognitive deficits and disorders. Our understanding of the potential cause of HIV-associated neurocognitive disorders (HAND) continues to develop on many fronts. Among them is the study of host genetics. Here, we review the most current information regarding the association between host genetics and risk for HIV infection, AIDS, and HAND. We focus on the role of dopamine dysfunction in the etiology of HAND, and propose a number of genetic polymorphisms within genes related to dopaminergic functioning and other neurobiological factors that may confer vulnerability or protection against HAND.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18264751      PMCID： PMC4433163          DOI： 10.1007/s10461-008-9360-x

Source DB:  PubMed          Journal:  AIDS Behav        ISSN： 1090-7165


  159 in total

1.  HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy.

Authors:  Jutta K Neuenburg; Hans R Brodt; Brian G Herndier; Markus Bickel; Peter Bacchetti; Richard W Price; Robert M Grant; Wolfgang Schlote
Journal:  J Acquir Immune Defic Syndr       Date:  2002-10-01       Impact factor: 3.731

Review 2.  The contribution of gene-environment interaction to psychopathology.

Authors:  Anita Thapar; Gordon Harold; Frances Rice; Kate Langley; Michael O'donovan
Journal:  Dev Psychopathol       Date:  2007

3.  Constitutive expression of stromal derived factor-1 by mucosal epithelia and its role in HIV transmission and propagation.

Authors:  W W Agace; A Amara; A I Roberts; J L Pablos; S Thelen; M Uguccioni; X Y Li; J Marsal; F Arenzana-Seisdedos; T Delaunay; E C Ebert; B Moser; C M Parker
Journal:  Curr Biol       Date:  2000-03-23       Impact factor: 10.834

4.  Estimation of the temporal probability of human immunodeficiency virus (HIV) dementia after risk stratification for HIV-infected persons.

Authors:  A I Qureshi; D L Hanson; J L Jones; R S Janssen
Journal:  Neurology       Date:  1998-02       Impact factor: 9.910

5.  Interleukin-2 up-regulates expression of the human immunodeficiency virus fusion coreceptor CCR5 by CD4+ lymphocytes in vivo.

Authors:  D Weissman; M Dybul; M B Daucher; R T Davey; R E Walker; J A Kovacs
Journal:  J Infect Dis       Date:  2000-03       Impact factor: 5.226

Review 6.  Brain-derived neurotrophic factor as a prototype neuroprotective factor against HIV-1-associated neuronal degeneration.

Authors:  R L Nosheny; I Mocchetti; A Bachis
Journal:  Neurotox Res       Date:  2005-10       Impact factor: 3.911

7.  Prevalence of cognitive disorders differs as a function of age in HIV virus infection.

Authors:  James T Becker; Oscar L Lopez; Mary Amanda Dew; Howard J Aizenstein
Journal:  AIDS       Date:  2004-01-01       Impact factor: 4.177

8.  C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo.

Authors:  M Hirvonen; A Laakso; K Någren; J O Rinne; T Pohjalainen; J Hietala
Journal:  Mol Psychiatry       Date:  2004-12       Impact factor: 15.992

9.  Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia.

Authors:  Malcolm J Avison; Avindra Nath; Robin Greene-Avison; Frederick A Schmitt; Rodney A Bales; As'ad Ethisham; Richard N Greenberg; Joseph R Berger
Journal:  J Neurovirol       Date:  2004-08       Impact factor: 2.643

10.  Association of a duplicated repeat polymorphism in the 5'-untranslated region of the DRD4 gene with novelty seeking.

Authors:  Geraldine Rogers; Peter Joyce; Roger Mulder; Douglas Sellman; Allison Miller; Melanie Allington; Robin Olds; Elisabeth Wells; Martin Kennedy
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2004-04-01       Impact factor: 3.568
View more
  14 in total

1.  Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.

Authors:  Andrew J Levine; Susan Service; Eric N Miller; Sandra M Reynolds; Elyse J Singer; Paul Shapshak; Eileen M Martin; Ned Sacktor; James T Becker; Lisa P Jacobson; Paul Thompson; Nelson Freimer
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2012-05-24       Impact factor: 3.568

Review 2.  Editorial neuroAIDS review.

Authors:  Paul Shapshak; Pandjassarame Kangueane; Robert K Fujimura; Deborah Commins; Francesco Chiappelli; Elyse Singer; Andrew J Levine; Alireza Minagar; Francis J Novembre; Charurut Somboonwit; Avindra Nath; John T Sinnott
Journal:  AIDS       Date:  2011-01-14       Impact factor: 4.177

3.  CCL3 genotype and current depression increase risk of HIV-associated dementia.

Authors:  Andrew J Levine; Elyse J Singer; Janet S Sinsheimer; Charles H Hinkin; Jeanette Papp; Sugandha Dandekar; Allison Giovanelli; Paul Shapshak
Journal:  Neurobehav HIV Med       Date:  2009-11

4.  Transcriptome analyses identify key cellular factors associated with HIV-1-associated neuropathogenesis in infected men.

Authors:  Narasimhan J Venkatachari; Siddhartha Jain; Leah Walker; Shalmali Bivalkar-Mehla; Ansuman Chattopadhyay; Ziv Bar-Joseph; Charles Rinaldo; Ann Ragin; Eric Seaberg; Andrew Levine; James Becker; Eileen Martin; Ned Sacktor; Velpandi Ayyavoo
Journal:  AIDS       Date:  2017-03-13       Impact factor: 4.177

5.  Ketone bodies protection against HIV-1 Tat-induced neurotoxicity.

Authors:  Liang Hui; Xuesong Chen; Dhaval Bhatt; Nicholas H Geiger; Thad A Rosenberger; Norman J Haughey; Susan A Masino; Jonathan D Geiger
Journal:  J Neurochem       Date:  2012-05-17       Impact factor: 5.372

Review 6.  The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.

Authors:  Bradley E Aouizerat; C Leigh Pearce; Christine Miaskowski
Journal:  Curr HIV/AIDS Rep       Date:  2011-03       Impact factor: 5.071

Review 7.  Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder.

Authors:  Andrew J Levine; Stella E Panos; Steve Horvath
Journal:  J Acquir Immune Defic Syndr       Date:  2014-04-01       Impact factor: 3.731

8.  HIV-1 envelope accessible surface and polarity: clade, blood, and brain.

Authors:  Gopichandran Sowmya; Gunasagaran Shamini; Sathyanarayanan Anita; Meena Sakharkar; Venkat Mathura; Hector Rodriguez; Andrew J Levine; Elyse Singer; Deborah Commins; Charurut Somboonwit; John T Sinnott; Harcharan S Sidhu; Ganapathy Rajaseger; Peter Natesan Pushparaj; Pandajarasamme Kangueane; Paul Shapshak
Journal:  Bioinformation       Date:  2011-03-22

9.  HIV associated dementia and HIV encephalitis II: Genes on chromosome 22 expressed in individually microdissected Globus pallidus neurons (Preliminary analysis).

Authors:  Paul Shapshak; Robert Duncan; Pandajarasamme Kangueane; Charurut Somboonwit; John Sinnott; Deborah Commins; Elyse Singer; Andrew Levine
Journal:  Bioinformation       Date:  2011-05-26

10.  Molecular epigenetics, chromatin, and NeuroAIDS/HIV: translational implications.

Authors:  Paul Shapshak; Francesco Chiappelli; Deborah Commins; Elyse Singer; Andrew J Levine; Charurut Somboonwit; Alireza Minagar; Andras J Pellionisz
Journal:  Bioinformation       Date:  2008-10-07
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.